Search Results

Overview

Uniprot IDH0VFP3
Protein NameExportin-5
Gene NameXPO5
OrganismCavia porcellus

Kla Sites from experimental identification

Position Flanking peptide
1106 LLNPSLQKVADKRRK

Function

Mediates the nuclear export of micro-RNA precursors, which form short hairpins. Also mediates the nuclear export of synthetic short hairpin RNAs used for RNA interference. In some circumstances can also mediate the nuclear export of deacylated and aminoacylated tRNAs. Specifically recognizes dsRNAs that lack a 5'-overhang in a sequence-independent manner, have only a short 3'-overhang, and that have a double-stranded length of at least 15 base-pairs. Binding is dependent on Ran-GTP

Protein Sequence

10 FCEEFKEKCP 20 ICVHCGLRLA 30 EKTQIAIVRH 40 FGLQILEHVV 50 KFRWNNMSRL 60 EKVFLKNSVM 70 ELIASGTMNI 80 LEEENHIKDG 90 LSRIVVEIIK 100 REWPQHWRDM 110 LAELDTLSRQ 120 GETQTELVMF 130 ILLRLAEDVV 140 TFQTLPSQRR 150 RDIQQTLTQN 160 MESIFSFLLN 170 TLQENVNKYQ 180 QMKTDASQES 190 KAQASCRVGI 200 AALNTLAGYI 210 DWVSMSHITA 220 ENCKLLEMLC 230 LLLNEQELQL 240 GAAECLLIAV 250 SRKGKLEDRK 260 PLMVLFGDVA 270 MHYILSAAQT 280 ADGGGLVEKH 290 YVFLKRLCQV 300 LCALGSQLCA 310 LLGGDSDVQT 320 PGNFGKYLES 330 FLAFTTHPSQ 340 FLRSSTQMTW 350 GALFRHEVLS 360 RDPVLLAILP 370 KYLRASMTNL 380 VKMGFPSKTD 390 SPSCEYSRYD 400 FDSDEDFNTF 410 FNSSRAQQGE 420 VMRMACRLDP 430 KTSFQMAGEW 440 LKYQLSTPVD 450 SGVMNSCSPA 460 AGTGEGTLCS 470 VFSPSFVQWE 480 AMTFFLESVI 490 NQMFRTLEKE 500 AIPVNDGIEL 510 LQMVLSFETK 520 DPLILSCVLT 530 NISALFSFVT 540 YRPEFLPQVF 550 SKLFSSVTFE 560 SIDENKAPRT 570 RAVRNVRRHA 580 CSSIIKMCRD 590 YPELVLPSFD 600 TLYSHVKQLF 610 SNELLLTQME 620 KCALMEALVL 630 ISNHFKNYER 640 QKMFLEELMA 650 PVASIWLSEE 660 MRRVLSDVDA 670 FLAYVGADVE 680 SCDPDVEDPC 690 GFNRARISFC 700 VYSILGVVKR 710 TCWPSDLEEA 720 KAGGFMVGYT 730 PSGSPIFRNP 740 CTEQVLKLLD 750 NLLALIRTHN 760 TLYAPEMQTK 770 MAEPFAKALD 780 MLEAEKSSIL 790 GLPQPLLELN 800 DYPVYKTVLE 810 RMQRFFSTLY 820 ENCFHILGKA 830 GPSMQQDFYT 840 VEDLATQLLG 850 SAFVNLNNIP 860 DYRLRPMLRV 870 FVKPLVLFCP 880 PEHYEALVSP 890 ILGPLFTYLH 900 MRLSQKWQVI 910 NQRSLLCGEE 920 ESVEENPESQ 930 EMLEEQLVRL 940 LTREVMDLIT 950 VCCVAKKSAD 960 HSAAPPADGE 970 DEEMMATEVT 980 PSAMAELTDL 990 GKCLMKHEDV 1000 CTALLITAFN 1010 SLAWKDTLSC 1020 QRTTTQLCWP 1030 LLKQVLSGTL 1040 LADAVTWLFT 1050 SVLKGLQTHG 1060 QHDGCMASLV 1070 HLAFQIYEAL 1080 RPRYLEIRAV 1090 MEQIPEIQKD 1100 SLDQFDCKLL 1110 NPSLQKVADK 1120 RRKDQFKRLI 1130 AGCIGKPLGE 1140 QFRKEVHIKN 1150 LPSLFKKTKP 1160 MMETEVLDND 1170 GGSLATIFEP

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0016442 RISC complex
Cellular Component GO:0042565 RNA nuclear export complex
Molecular Function GO:0003729 mRNA binding
Molecular Function GO:0005049 nuclear export signal receptor activity
Molecular Function GO:0070883 pre-miRNA binding
Molecular Function GO:1905172 RISC complex binding
Molecular Function GO:0031267 small GTPase binding
Molecular Function GO:0000049 tRNA binding
Biological Process GO:0035281 pre-miRNA export from nucleus
Biological Process GO:0006611 protein export from nucleus

Reference

[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.