Overview
| Uniprot ID | H0VG23 |
|---|
| Protein Name | Regulator of chromosome condensation |
|---|
| Gene Name | RCC1 |
|---|
| Organism | Cavia porcellus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 32 |
DSRNQAVKLTTSRGG |
Function
Guanine-nucleotide releasing factor that promotes the exchange of Ran-bound GDP by GTP, and thereby plays an important role in RAN-mediated functions in nuclear import and mitosis. Contributes to the generation of high levels of chromosome-associated, GTP-bound RAN, which is important for mitotic spindle assembly and normal progress through mitosis. Via its role in maintaining high levels of GTP-bound RAN in the nucleus, contributes to the release of cargo proteins from importins after nuclear import. Involved in the regulation of onset of chromosome condensation in the S phase. Binds both to the nucleosomes and double-stranded DNA
Protein Sequence
10
MPPKRVAKRA
20
SPPEDAVPKS
30
KKVKDSRNQA
40
VKLTTSRGGP
50
STHSCQVSHR
60
SHSTASGMVL
70
TLGQGDVGQL
80
GLGESVMERK
90
KPALVPIPEE
100
VVQAEAGGMH
110
TVCLSKSGQI
120
YSFGCNDEGA
130
LGRDTSVEGS
140
EMVPGKVELQ
150
EKVVQVSAGD
160
SHTAALTEDG
170
RVFLWGSFRD
180
NNGVIGLLEP
190
MKKSMVPVQV
200
ELDVPVVKVA
210
SGNDHLVMLT
220
VDGDLYTLGC
230
GEQGQLGRVP
240
ELFANRGGRK
250
GLERLLVPKC
260
VMLKSRGSRG
270
YVRFQDAFCG
280
AYFTFAISHE
290
GHVYGFGLSN
300
YHQLGTPGTE
310
SCFVPQNLTS
320
FKNSTKSWVG
330
FSGGQHHTIC
340
MDSEGNAYSL
350
GRAEYGRLGL
360
GEGAEEKSIP
370
TLISRLPCVS
380
SVACGASVGY
390
AVTKDGRVFA
400
WGMGTNYQLG
410
TGQDDDAWSP
420
VEMTGKQLEN
430
RVVLSVSSGG
440
QHTVLLVKDK
EQS
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005694 |
chromosome |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005634 |
nucleus |
| Molecular Function |
GO:0003677 |
DNA binding |
| Molecular Function |
GO:0005085 |
guanyl-nucleotide exchange factor activity |
| Biological Process |
GO:0051301 |
cell division |
Reference
[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.