Overview
| Uniprot ID | H0VG43 |
|---|
| Protein Name | Sorting nexin-2 |
|---|
| Gene Name | SNX2 |
|---|
| Organism | Cavia porcellus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 287 |
GILRMVNKAADAVNK |
Function
Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC). Can sense membrane curvature and has in vitro vesicle-to-membrane remodeling activity. Required for retrograde endosome-to-TGN transport of TGN38. Promotes KALRN- and RHOG-dependent but retromer-independent membrane remodeling such as lamellipodium formation; the function is dependent on GEF activity of KALRN
Protein Sequence
10
MAAEREPPPL
20
GDGKPNDFEE
30
LEDGEDLFTS
40
TVSTLESSPS
50
SPEPASLPTE
60
DISANSNGPK
70
PSEVVLDDDR
80
EDLFAEATEE
90
VSLDSPERDP
100
ILSSEPSPAI
110
TPVTPTTLIA
120
PRMESKSMSA
130
PVIFDRSREE
140
IEEEANGDIF
150
DIEIGVSDPE
160
KVGDGMNAYM
170
AYRVTTKTSL
180
SMFSKSEFSV
190
KRRFSDFLGL
200
HSKLASKYLH
210
VGYIVPPAPE
220
KSIVGMTKVK
230
VGKEDSSSTE
240
FVEKRRAALE
250
RYLQRTVKHP
260
TLLQDPDLRQ
270
FLESSELPRA
280
VNTQALSGAG
290
ILRMVNKAAD
300
AVNKMTIKMN
310
ESDAWFEEKQ
320
QQFENLDQQL
330
RKLHTSVEAL
340
VCHRKELSAN
350
TAAFAKSAAM
360
LGNSEDHTAL
370
SRALSQLAEV
380
EEKIDQLHQE
390
QAFADFYMFS
400
ELLSDYIRLI
410
SAVKGVFDHR
420
MKCWQKWEDA
430
QITLLKKRET
440
EAKMMVANKP
450
DKIQQAKNEI
460
REWEAKVQQG
470
ERDFEQISKT
480
IRKEVGRFEK
490
ERVKDFKTVI
500
IKYLESLVQT
510
QQQLIKYWEA
FLPEAKAIA
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0031901 |
early endosome membrane |
| Cellular Component |
GO:0030027 |
lamellipodium |
| Cellular Component |
GO:0030905 |
retromer, tubulation complex |
| Molecular Function |
GO:0005154 |
epidermal growth factor receptor binding |
| Molecular Function |
GO:0005158 |
insulin receptor binding |
| Molecular Function |
GO:1990460 |
leptin receptor binding |
| Molecular Function |
GO:0035091 |
phosphatidylinositol binding |
| Molecular Function |
GO:0046982 |
protein heterodimerization activity |
| Molecular Function |
GO:0042803 |
protein homodimerization activity |
| Molecular Function |
GO:1990459 |
transferrin receptor binding |
| Biological Process |
GO:0034498 |
early endosome to Golgi transport |
| Biological Process |
GO:0006886 |
intracellular protein transport |
| Biological Process |
GO:0072673 |
lamellipodium morphogenesis |
Reference
[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.