Search Results

Overview

Uniprot IDH0VGK4
Protein NameCap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1
Gene NameCMTR1
OrganismCavia porcellus

Kla Sites from experimental identification

Position Flanking peptide
114 GKFSQGRKDIIEASN
123 IIEASNQKGRRGLGL
14 PECTAPLKKQKKRVA

Function

S-adenosyl-L-methionine-dependent methyltransferase that mediates RNA cap1 2'-O-ribose methylation to the 5'-cap structure of RNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA to produce m(7)GpppNmp (cap1)

Protein Sequence

10 MKRRIDPECT 20 APLKKQKKRV 30 AELALSLSST 40 SDDEPSTPVS 50 HAAKVSATSL 60 SESDSENEGK 70 PRGSDAFNDV 80 FRADSLVEGT 90 SSRYSMYNSV 100 SQKLMAKMGF 110 KEGEGLGKFS 120 QGRKDIIEAS 130 NQKGRRGLGL 140 TLQGFDQELN 150 VDWRDEPEPS 160 ACEQVSWFPE 170 CTMEIPDTQE 180 MSDWMVVGKR 190 KMIIEDETEF 200 CSAELLHSML 210 QCKCVFDDLD 220 GEEMRRARTR 230 ANPYEMIRGV 240 FFLNRAAMKM 250 ANMDFVFDRM 260 FTNPRDSKGL 270 PLVKDRNAEL 280 LYFADVCAGP 290 GGFSEYVLWR 300 KKWHAKGFGM 310 TLKGPNDFKL 320 EDFYSASSEL 330 FEPYYGEGGV 340 DGDGDITRPE 350 NVTAFRNFVL 360 DNTDRKGVHF 370 LMADGGFSVE 380 GQECLQEILS 390 KQLLLCQFLM 400 ALSVVRTGGH 410 FICKTFDLFT 420 PFSVGLIYLL 430 YCCFERVCLF 440 KPVTSRPANS 450 ERYVVCKGLK 460 VGTDDVREYL 470 FSVNMKLNQL 480 RNTESDVNLV 490 VPLKVIKEDP 500 EFTDYMIRSN 510 ESHCSLQIKA 520 LAKIHAFVQD 530 TTLSEPRQAE 540 IRKECLRLWE 550 IPDHARVAPS 560 SSDPKSKFFE 570 LIQGAEIDVF 580 SYKPTLLTTK 590 TLERIRPVLD 600 YRCMVSGSQQ 610 KFLLGMGKSQ 620 IYTWDGRQSD 630 RWVKLDLKTE 640 LPRDTLLSVE 650 IVHELKGEGK 660 AQRKISAIHI 670 LDVLVLNGSD 680 VRDQHFNQRI 690 QLAEKFVKAV 700 SKPSRPDMNP 710 IRVKEVYRLE 720 EVEKIFLRLE 730 MKVIKGSSGT 740 PRLSYTGRDD 750 RHFVPTGLYI 760 VRTVNEPWTM 770 GFSKSVQRKF 780 FYNKKTREST 790 FSMPIDSIAP 800 FHVCYISRLF 810 WEWGDGIRVH 820 DSQKPQDLDK 830 LSKEDVLTFI HTTHSH

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005654 nucleoplasm
Molecular Function GO:0004483 methyltransferase cap1 activity
Molecular Function GO:0003676 nucleic acid binding
Biological Process GO:0006370 7-methylguanosine mRNA capping
Biological Process GO:0032259 methylation
Biological Process GO:0016556 mRNA modification

Reference

[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.