Search Results
Overview
| Uniprot ID | H0VGS0 |
|---|---|
| Protein Name | Calretinin |
| Gene Name | CALB2 |
| Organism | Cavia porcellus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 233 | DLYEKNKKEMNIQQL |
| 60 | KGSGMTSKSDNLGEK |
Function
Calcium-binding protein involved in calcium homeostasis and signal transduction. It plays a critical role in buffering intracellular calcium levels and modulating calcium-dependent signaling pathways. Predominantly expressed in specific neuronal populations, influences synaptic plasticity and neuronal excitability, contributing to learning and memory. During embryonic development, it facilitates neuronal differentiation and maturation
Protein Sequence
10
MAGPQQQPPY
20
LHLAELTASQ
30
FLEIWKHFDA
40
DGNGYIEGKE
50
LENFFQELEK
60
ARKGSGMTSK
70
SDNLGEKMKE
80
FMQKYDKNSD
90
GKIEMAELAQ
100
ILPTEENFLL
110
CFRQHVGSSA
120
EFMEAWRKYD
130
TDRSGYIEAN
140
ELKGFLSDLL
150
KKANRPYDEP
160
KLQEYTQTIL
170
RMFDLNGDGK
180
LGLSEMSRLL
190
PVQENFLLKF
200
QGMKLTSEEF
210
NAIFTFYDKD
220
GSGYIDENEL
230
DALLKDLYEK
240
NKKEMNIQQL
250
TNYRKSVMSL
260
AEAGKLYRKD
270
LEIVLCSEPP
M
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0044293 | dendriole |
| Cellular Component | GO:0005921 | gap junction |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0098688 | parallel fiber to Purkinje cell synapse |
| Cellular Component | GO:0043195 | terminal bouton |
| Molecular Function | GO:0099534 | calcium ion binding involved in regulation of presynaptic cytosolic calcium ion concentration |
| Biological Process | GO:1900271 | regulation of long-term synaptic potentiation |
| Biological Process | GO:0099536 | synaptic signaling |
Reference
[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.