Search Results

Overview

Uniprot IDH0VGW0
Protein NameSymplekin
Gene NameSYMPK
OrganismCavia porcellus

Kla Sites from experimental identification

Position Flanking peptide
490 KPESVLIKRRLSAQG

Function

Scaffold protein that functions as a component of a multimolecular complex involved in histone mRNA 3'-end processing. Specific component of the tight junction (TJ) plaque, but might not be an exclusively junctional component. May have a house-keeping rule. Is involved in pre-mRNA polyadenylation. Enhances SSU72 phosphatase activity

Protein Sequence

10 MASGSGDNVT 20 RRSVASQFFT 30 QEEGPGIDGM 40 TTSERVVDLL 50 NQAALITNDS 60 KITVLKQVQE 70 LIINKDPTLL 80 DNFLDEIIAF 90 QADKSIEVRK 100 FVIGFIEEAC 110 KRDIELLLKL 120 IANLNMLLRD 130 ENVNVVKKAI 140 LTMTQLYKVA 150 LQWMVKSRVI 160 SDLQEACWDM 170 VSAMAGDIIL 180 LLDSDNDGIR 190 THAIKFVEGL 200 IVTLSPRMAD 210 SEVPRRQEHD 220 ISLDRIPRDH 230 PYIQYNVLWE 240 EGKAALEQLL 250 KFMVHPAISS 260 INLTTALGSL 270 ANIARQRPMF 280 MSEVIQAYET 290 LHANLPPTLA 300 KSQVSSVRKN 310 LKLHLLSVLK 320 HPASLEFQAQ 330 ISTLLVDLGT 340 PQAEIARNMP 350 SGKDARKRPR 360 DDSDSTLKKM 370 KLEPNLGEDD 380 EDKDLEPGPS 390 GTSKASAQIS 400 GQSDTDITAE 410 FLQPLLTPDN 420 VANLVLISMV 430 YLPETMPASF 440 QAIYTPVESA 450 GTEAQIKHLA 460 RLMATQMTAA 470 GLGPGVEQTK 480 QCKEEPKEEK 490 VVKPESVLIK 500 RRLSAQGQAI 510 SVVGSLSSMS 520 PLEEEVPQAK 530 RRPEPIIPVT 540 QPRLGGAGGR 550 KKIFRLSEVL 560 KPLTDAEVEA 570 MKLGAVKRIL 580 RAEKAVACSG 590 AAQVRIKILA 600 TLVTQFHSGL 610 KAEVLSFILE 620 DVRARLDLAF 630 AWLYQEYNAY 640 LAAGSSGFLD 650 KYEDCLIRLL 660 SGLQEKPDQK 670 DGIFTKVVLE 680 APLITESALE 690 VIRKYCEDES 700 RTYLGMSTLR 710 DLIFKRPSRQ 720 FQYLHVLLDL 730 SSHEKDKVRS 740 QALLFIKRMY 750 EKEQLREYVE 760 KFALNYLQLL 770 VHPNPPSVLF 780 GADKDTEVAA 790 PWTEETVKQC 800 LYLYLALLPQ 810 NHKLIHELAA 820 VYTEAIADIK 830 RTVLRVIEQP 840 IRGMGMNSPE 850 LLLLVENCPK 860 GAETLVTRCL 870 HSLTDKVPPS 880 PELVKRVRDL 890 YHKRLPDVRF 900 LIPVLNGLEK 910 KEVIQALPKL 920 IKLNPIVVKE 930 VFNRLLGTQH 940 GEGNSALSPL 950 NPGELLIALH 960 NIDSVKCDMK 970 SIIKATNLCF 980 AERNVYTSEV 990 LAVVMQQLME 1000 QSPLPMLLMR 1010 TVIQSLTMYP 1020 RLGGFVMNIL 1030 SRLIMKQVWK 1040 YPKVWEGFIK 1050 CCQRTKPQSF 1060 QVILQLPPQQ 1070 LGAVFDKCPE 1080 LREPLLAHVR 1090 SFTPHQQAHI 1100 PNSIMTILEA 1110 SGKQEPEAKD 1120 TPAGPLEEDD 1130 LEPLALAPAP 1140 ASRPPQDLIG 1150 LRLAQEKALK 1160 HRRGLEPDRG 1170 APAQGRSGSR 1180 RRTGIQAQRW 1190 GKERAGRGPA 1200 LDPLPFAFSC 1210 HQEAAASGLT 1220 AKEERSPQAL 1230 APAGEDAAVK 1240 TPSPAPEETG DPETKGNS

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005923 bicellular tight junction
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005856 cytoskeleton
Cellular Component GO:0005847 mRNA cleavage and polyadenylation specificity factor complex
Cellular Component GO:0097165 nuclear stress granule
Cellular Component GO:0005886 plasma membrane
Biological Process GO:0007155 cell adhesion
Biological Process GO:0031124 mRNA 3'-end processing

Reference

[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.