Search Results

Overview

Uniprot ID	H0VHR6
Protein Name	ATP-citrate synthase
Gene Name	ACLY
Organism	Cavia porcellus

Kla Sites from experimental identification

Position	Flanking peptide
478	KPAVLQGKSATLFSR

Function

Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate in multiple biochemical reactions in protein, carbohydrate and lipid metabolism

Protein Sequence

10 MSAKAISEQT 20 GKELLYKYIC 30 TTSAIQNRFR 40 YARVTPDTDW 50 ARLLQDHPWL 60 LSQSLVVKPD 70 QLIKRRGKLG 80 LVGINLSLDG 90 VKSWLKPRLG 100 QEAVVGKARG 110 FLKNFLIEPF 120 VPHSQAEEFY 130 VCIYAAREGD 140 YVLFHHEGGV 150 DVGDVDAKAQ 160 KLLVGVDKKL 170 SSEDVREHLL 180 VHVPADKKEV 190 LASFICGLFN 200 FYEDLYFTYL 210 EINPLVVTKD 220 GVYVLDLAAK 230 VDATADYICK 240 VKWGDIEFPP 250 PFGREAYPEE 260 AYIADLDAKS 270 GASLKLTLLN 280 PKGRIWTMVA 290 GGGASVVYSD 300 TICDLGGVNE 310 LANYGEYSGA 320 PSEQQTYDYA 330 KTILSLMTRE 340 KHPEGKILII 350 GGSIANFTNV 360 AATFKGIVRA 370 IRDYQGPLKE 380 HEVTIFVRRG 390 GPNYQEGLRV 400 MGEVGKTTGI 410 PIHVFGTETH 420 MTAIVGMALG 430 HRPIPNQPPM 440 AAHTANFLLN 450 ASGSTSTPAP 460 SRTASFSESR 470 ADEVAPAKKA 480 KPAVLQGKSA 490 TLFSRHTKAI 500 VWGMQTRAVQ 510 GMLDFDYVCS 520 RDEPSVAAMV 530 YPFTGDHKQK 540 FYWGHKEILI 550 PVFKNMGDAM 560 KKHPEVDVLI 570 NFASLRSAYD 580 STMETMNHAQ 590 IRTIAIIAEG 600 IPEALTRKLI 610 QTAERKGVTI 620 IGPATVGGIK 630 PGCFKIGNTG 640 GMLDNILASK 650 LYRPGSVAYV 660 SRSGGMSNEL 670 NNIISRTTDG 680 VYEGVAIGGD 690 RYPGSTFMDH 700 VLRYQDTPGV 710 KMIVVLGEIG 720 GTEEYKICSA 730 IQEGRLTKPV 740 VCWCIGTCAT 750 MFSSEVQFGH 760 AGACANQASE 770 TAVAKNQALK 780 EAGVFVPRSF 790 DELGEIIQSV 800 YEDLVTRGVI 810 VPAQEVPPPT 820 VPMDYSWARE 830 LGLIRKPASF 840 MTSICDERGQ 850 ELIYAGMPIT 860 EVFKEEMGIG 870 GVLGLLWFQR 880 RLPKYACQFI 890 EMCLMVTADH 900 GPAVSGAHNT 910 IICARAGKDL 920 VSSLTSGLLT 930 IGDRFGGALD 940 AAAKMFSKAF 950 DSGMIPMEFV 960 NKMKKEGKLI 970 MGIGHRVKSI 980 NNPDMRVQIL 990 KDFVRQHFPA 1000 LPLLDYALQV 1010 EKITTSKKPN 1020 LILNVDGLIG 1030 VAFVDMLRNC 1040 GSFTREEADE 1050 YIDIGALNGI 1060 FVLGRSMGFI 1070 GHYLDQKRLK 1080 QGLYRHPWDD 1090 ISYVLPEHMS M

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005829	cytosol
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0003878	ATP citrate synthase activity
Molecular Function	GO:0046872	metal ion binding
Biological Process	GO:0006085	acetyl-CoA biosynthetic process
Biological Process	GO:0006101	citrate metabolic process
Biological Process	GO:0006633	fatty acid biosynthetic process

Reference

[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.