Search Results
Overview
| Uniprot ID | H0VHT8 |
|---|---|
| Protein Name | Lysophospholipase-like protein 1 |
| Gene Name | LYPLAL1 |
| Organism | Cavia porcellus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 236 | KLPGETGKHNE**** |
Function
Palmitoyl thioesterase that catalyzes depalmitoylation of CGAS and KCNMA1. Acts as a regulator of innate immunity by mediating depalmitoylation of CGAS, thereby preventing CGAS homodimerization and cyclic GMP-AMP synthase activity. Does not exhibit phospholipase nor triacylglycerol lipase activity, able to hydrolyze only short chain substrates due to its shallow active site
Protein Sequence
10
MAAAWGPGGL
20
QRCVVSPSGR
30
HSASLIFLHG
40
SGDSGQGLRR
50
WIKEVLSQDL
60
TFQHIKIIYP
70
TAPPRPYTPM
80
RGRISNVWFD
90
RLKISNDCPE
100
HLESIDRMCR
110
ELTELIDEEV
120
SGGISKRRIL
130
LGGFSMGGCM
140
AMHLAYRNHR
150
DVAGVFALSS
160
FLNKASAVYQ
170
ALQKSDGVLP
180
ELFQCHGTAD
190
ELVLHSWGEE
200
TNSALKSLGV
210
STKFHSFPSM
220
YHELSKTELE
230
QLKSWILTKL
PGETGKHNE
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Molecular Function | GO:0052689 | carboxylic ester hydrolase activity |
| Molecular Function | GO:0008474 | palmitoyl-(protein) hydrolase activity |
| Biological Process | GO:0160049 | negative regulation of cGAS/STING signaling pathway |
Reference
[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.