Search Results
Overview
| Uniprot ID | H0VII1 |
|---|---|
| Protein Name | Histone H1.0 |
| Gene Name | H1-0 |
| Organism | Cavia porcellus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 52 | SSRQSIQKYVKSHYK |
| 59 | KYVKSHYKVGENADS |
| 82 | LVTTGVLKQTKGVGA |
| 85 | TGVLKQTKGVGASGS |
| 97 | SGSFRLAKSDEPKRA |
Function
Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers and promote formation of the H3K27me3 mark by the PRC2/EED-EZH2 complex. The histones H1.0 are found in cells that are in terminal stages of differentiation or that have low rates of cell division
Protein Sequence
10
MTENSTSTPA
20
AKPKRAKASK
30
KSTDHPKYSD
40
MIVAAIQAEK
50
NRAGSSRQSI
60
QKYVKSHYKV
70
GENADSQIKL
80
SIKRLVTTGV
90
LKQTKGVGAS
100
GSFRLAKSDE
110
PKRAVAFKKT
120
KKEVKKVATP
130
KKAAKPKKAA
140
SKAPSKKPKA
150
TPVKKAKKKP
160
AATPKKAKKP
170
KVVKAKPVKA
180
SKPKKAKPVK
190
PKAKSSAKRA
GKKK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0000791 | euchromatin |
| Cellular Component | GO:0016604 | nuclear body |
| Cellular Component | GO:0000786 | nucleosome |
| Cellular Component | GO:0017053 | transcription repressor complex |
| Molecular Function | GO:0003690 | double-stranded DNA binding |
| Molecular Function | GO:0003680 | minor groove of adenine-thymine-rich DNA binding |
| Molecular Function | GO:0031492 | nucleosomal DNA binding |
| Molecular Function | GO:0030527 | structural constituent of chromatin |
| Biological Process | GO:0030261 | chromosome condensation |
| Biological Process | GO:0031507 | heterochromatin formation |
| Biological Process | GO:0045910 | negative regulation of DNA recombination |
| Biological Process | GO:0006334 | nucleosome assembly |
Reference
[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.