Search Results

Overview

Uniprot ID	H0VJ73
Protein Name	Cleavage and polyadenylation specificity factor subunit 1
Gene Name	CPSF1
Organism	Cavia porcellus

Kla Sites from experimental identification

Position	Flanking peptide
1312	ATEGPSKKSVVWENK
898	KPKPSKKKAEGGSTD

Function

Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. This subunit is involved in the RNA recognition step of the polyadenylation reaction. May play a role in eye morphogenesis and the development of retinal ganglion cell projections to the midbrain

Protein Sequence

10 MYAVYKQAHP 20 PTGLEFAMYC 30 NFFNNSERNL 40 VVAGTSQLYV 50 YRLNRDAEAL 60 TKNDRPTEGK 70 SHREKLGAGG 80 PPSLSFGNVM 90 SMATLISFPQ 100 LSVVEYDPGT 110 HDLKTLSLHY 120 FEEPELRDGF 130 VQNVHTPRVR 140 VDPDGRCAAM 150 LIYGTRLVVL 160 PFRRESLAEE 170 HEGLVGEGQR 180 SSFLPSYIID 190 VRALDEKLLN 200 IVDLQFLHGY 210 YEPTLLILFE 220 PNQTWPGRVA 230 VRQDTCSIVA 240 ISLNITQKVH 250 PVIWSLTSLP 260 FDCTQALAVP 270 KPIGGVVIFA 280 VNSLLYLNQS 290 VPPYGVALNS 300 LTLGTTAFPL 310 RTQEGVRITL 320 DCAQAAFISY 330 DKMVISLKGG 340 EIYVLTLITD 350 GMRSVRAFHF 360 DKAAASVLTT 370 SMVTMEPGYL 380 FLGSRLGNSL 390 LLKYTEKLQE 400 PPASTVREAA 410 DKEEPPSKKK 420 RVDSTAGWAG 430 SKTVPQDEVD 440 EIEVYGSEAQ 450 SGTQLATYSF 460 EVCDSMLNIG 470 PCANAAVGEP 480 AFLSEEFQNS 490 PEPDLEIVVC 500 SGYGKNGALS 510 VLQKSIRPQV 520 VTTFELPGCY 530 DMWTVIAPVR 540 KEEEETPKAE 550 GSEQEPSAPE 560 AEDDGRRHGF 570 LILSREDSTM 580 ILQTGQEIME 590 LDTSGFATQG 600 PTVFAGNIGD 610 NRYIVQVSPL 620 GIRLLEGVNQ 630 LHFIPVDLGA 640 PIVQCAVADP 650 YVVIMSAEGH 660 VTMFLLKSDS 670 YGGRHHRLAL 680 HKPPLHHQSK 690 VITLCLYRDV 700 SGMFTTESRL 710 GGARDELGGR 720 SSLEAEGLGS 730 ETSPTVDDEE 740 EMLYGDSSSL 750 FSPSKEEARR 760 NSQPPADREP 770 TPFRAEPTHW 780 CLLVRENGTM 790 EIYQLPDWRL 800 VFLVKNFPVG 810 QRVLVDSSSG 820 QPTTQGEVRK 830 EEATRQGELP 840 LVKEVLLVAL 850 GSRQSRPYLL 860 VHVDQELLIY 870 EAFPHDSQLG 880 QGNLKVRFKK 890 VPHNINFREK 900 KPKPSKKKAE 910 GGSTDEGSGV 920 RGRVARFRYF 930 EDIYGYSGVF 940 ICGPSPHWLL 950 VTGRGALRLH 960 PMGIDGPIDS 970 FAPFHNVNCP 980 RGFLYFNRQG 990 ELRISVLPAY 1000 LSYDAPWPVR 1010 KIPLRCTAHY 1020 VAYHVESKVY 1030 AVATSTSTPC 1040 TRIPRMTGEE 1050 KEFEAIERDD 1060 RYIHPQQEAF 1070 SIQLISPVSW 1080 EAIPNARIEL 1090 EEWEHVTCMK 1100 TVSLRSEETV 1110 SGLKGYVAAG 1120 TCLMQGEEVT 1130 CRGRILIMDV 1140 IEVVPEPGQP 1150 LTKNKFKVLY 1160 EKEQKGPVTA 1170 LCHCNGHLVS 1180 AIGQKIFLWS 1190 LRASELTGMA 1200 FIDTQLYIHQ 1210 MISVKNFILA 1220 ADVMKSISLL 1230 RYQEESKTLS 1240 LVSRDAKPLE 1250 VYSVDFMVDN 1260 AQLGFLVSDR 1270 DRNLMVYMYL 1280 PEAKESFGGM 1290 RLLRRADFHV 1300 GAHVNTFWRT 1310 PCRGATEGPS 1320 KKSVVWENKH 1330 ITWFATLDGG 1340 IGLLLPMQEK 1350 TYRRLLMLQN 1360 ALTTMLPHHA 1370 GLNPRAFRML 1380 HVDRRILQNA 1390 VRNVLDGELL 1400 NRYLYLSTME 1410 RGELAKKIGT 1420 TPDIILDDLL ETDRVTAHF

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005847	mRNA cleavage and polyadenylation specificity factor complex
Cellular Component	GO:0005654	nucleoplasm
Molecular Function	GO:0019899	enzyme binding
Molecular Function	GO:0035925	mRNA 3'-UTR AU-rich region binding
Biological Process	GO:0031124	mRNA 3'-end processing

Reference

[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.