Search Results
Overview
| Uniprot ID | H0VJX1 |
|---|---|
| Protein Name | E3 ubiquitin-protein ligase ZFP91 |
| Gene Name | ZFP91 |
| Organism | Cavia porcellus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 291 | EYCARAFKSSHNLAV |
| 81 | NTRSSRSKTGSLQLI |
Function
DNA-binding transcription factor. Also acts as an atypical E3 ubiquitin-protein ligase that mediates 'Lys-63'-linked ubiquitination of MAP3K14/NIK, leading to stabilize and activate MAP3K14/NIK. It thereby acts as an activator of the non-canonical NF-kappa-B2/NFKB2 pathway. May also play an important role in cell proliferation and/or anti-apoptosis
Protein Sequence
10
PAPGPPTARA
20
AACGTKPPSP
30
AQGKRSPRLV
40
RADPAPEEDS
50
SALAQEVSGV
60
ATRPGRGWRS
70
SSRTSGSRVR
80
DTENTRSSRS
90
KTGSLQLICK
100
SEPITDQLDY
110
EVADEHQSQS
120
PGGISDEEEE
130
EEEEEMLISE
140
EEIPFKDDPR
150
DETYKPHLER
160
ETPKPRRKSG
170
KVKEEKEKKE
180
IKVEVEVEVK
190
EEENEIREDE
200
EPPRKRGRRR
210
KDDKSPRLPK
220
RRKKPPIQYV
230
RCEMEGCGTV
240
LAHPRYLQHH
250
IKYQHLLKKK
260
YVCPHPSCGR
270
LFRLQKQLLR
280
HAKHHTDQRD
290
YICEYCARAF
300
KSSHNLAVHR
310
MIHTGEKPLQ
320
CEICGFTCRQ
330
KASLNWHMKK
340
HDADSFYQFS
350
CNICGKKFEK
360
KDSVVAHKAK
370
SHPEVLIAEA
380
LAANAGALIT
390
STDILGPNPE
400
SLAQPADAQG
410
LPLLSEPLGN
420
SASGECLLLE
430
AEGMSKSYCG
440
GAERVSLMAD
450
GKLFVGSGGS
460
SGGPEGLVMN
470
SDILGATTEV
480
LIEDSDSAGP
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005730 | nucleolus |
| Cellular Component | GO:0005654 | nucleoplasm |
| Molecular Function | GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific |
| Molecular Function | GO:0061630 | ubiquitin protein ligase activity |
| Molecular Function | GO:0008270 | zinc ion binding |
| Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| Biological Process | GO:0070534 | protein K63-linked ubiquitination |
Reference
[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.