Search Results
Overview
| Uniprot ID | H0VKN9 |
|---|---|
| Protein Name | Tubulin-folding cofactor B |
| Gene Name | TBCB |
| Organism | Cavia porcellus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 117 | SQEAYDQKQGTVRSF |
Function
Binds to alpha-tubulin folding intermediates after their interaction with cytosolic chaperonin in the pathway leading from newly synthesized tubulin to properly folded heterodimer. Involved in regulation of tubulin heterodimer dissociation. May function as a negative regulator of axonal growth
Protein Sequence
10
MEVTRMTAPT
20
VTVFISSSLN
30
SFRSEKRYSR
40
SLTIAEFKCK
50
LELVVGSPAS
60
CMQLELYGAD
70
DKFYCKLDQE
80
DALLGSYPVD
90
DGCRIHVIDH
100
SGARLGEYED
110
VSKVEKYEIS
120
QEAYDQKQGT
130
VRSFLKRSKL
140
GRYNEEERAQ
150
QEAEAAQRLI
160
EEKALASTIS
170
VGSRCEVRMP
180
GQSPRRGTVM
190
YVGLTDFKPG
200
YWIGVRYDEP
210
LGKNDGSVNG
220
KRYFECQAKY
230
GAFVKPSVVT
240
VGDFPEEDYG
LDEM
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005938 | cell cortex |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0035371 | microtubule plus-end |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0043014 | alpha-tubulin binding |
| Molecular Function | GO:0051010 | microtubule plus-end binding |
| Biological Process | GO:0030154 | cell differentiation |
| Biological Process | GO:0031122 | cytoplasmic microtubule organization |
| Biological Process | GO:0007399 | nervous system development |
| Biological Process | GO:0007023 | post-chaperonin tubulin folding pathway |
| Biological Process | GO:0007021 | tubulin complex assembly |
Reference
[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.