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Overview

Uniprot ID	H0VKV1
Protein Name	Synaptojanin-1
Gene Name	SYNJ1
Organism	Cavia porcellus

Kla Sites from experimental identification

Position	Flanking peptide
449	GTGALEGKAKLKDGA

Function

Phosphatase that acts on various phosphoinositides, including phosphatidylinositol 4-phosphate, phosphatidylinositol (4,5)-bisphosphate and phosphatidylinositol (3,4,5)-trisphosphate. Has a role in clathrin-mediated endocytosis. Hydrolyzes PIP2 bound to actin regulatory proteins resulting in the rearrangement of actin filaments downstream of tyrosine kinase and ASH/GRB2

Protein Sequence

10 MAFSKGFRIY 20 HKLDPPPFSL 30 IVETRQKEEC 40 LMFESGAVAV 50 LSSAEKEAIK 60 STYSKVLDAY 70 GLLGVLRLNL 80 GDTMLHYLVL 90 VTGCMSVGKI 100 QESEVFRVTS 110 TEFISLRVDA 120 SDEDRISEVR 130 KVLNSGNFYF 140 AWSASGSSLD 150 LSLNAHRSMQ 160 EHTTDNRFFW 170 NQSLHLHLKH 180 YGVNCDDWLL 190 RLMCGGVEIR 200 TIYAAHKQAK 210 ACLISRLSCE 220 RAGTRFNVRG 230 TNDDGHVANF 240 VETEQVVYLD 250 DSVSSFIQIR 260 GSVPLFWEQP 270 GLQVGSHRVR 280 MSRGFEANAP 290 AFDRHFRTLK 300 NLYGKQIVVN 310 LLGSKEGEHM 320 LSKAFQSHLK 330 ASEHAADIHM 340 VNFDYHQMVK 350 GGKAEKLHSV 360 LKPQVQKFLD 370 YGFFYFNGSE 380 VQRCQSGTVR 390 TNCLDCLDRT 400 NSVQAFLGLE 410 MLAKQLEALG 420 LAEKPQLVTR 430 FQEVFRSMWS 440 VNGDSISKIY 450 AGTGALEGKA 460 KLKDGARSVT 470 RTIQNNFFDS 480 SKQEAIDVLL 490 LGNTLNSDLA 500 DKARALLTTG 510 SLRVSEQTLQ 520 SASSKVLKSM 530 CENFYKYSKP 540 KKIRVCVGTW 550 NVNGGKQFRS 560 IAFKNQTLTD 570 WLLDAPKLAG 580 IQDFQDQRSK 590 PTDIFAIGFE 600 EMVELNAGNI 610 VNASTTNQKL 620 WAVELQKTIS 630 RDNKYVLLAS 640 EQLVGVCLFV 650 FIRPQHAPFI 660 RDVAVDTVKT 670 GMGGATGNKG 680 AVAIRMLFHT 690 TSLCFVCSHF 700 AAGQSQVKER 710 NEDFIEIARK 720 LSFPMGRLLF 730 SHDYVFWCGD 740 FNYRIDLPNE 750 EVKELIRQQN 760 WDSLIAGDQL 770 INQKNAGQIF 780 RGFLEGKVTF 790 APTYKYDLFS 800 DDYDTSEKCR 810 TPAWTDRILW 820 RRRKWPFDRS 830 AEDLDLLNAS 840 FQDESKILYT 850 WTPGTLLHYG 860 RAELKTSDHR 870 PVVALIDIDI 880 FEVEAEERQN 890 IYKEVIAIQG 900 PPDGTVLVSI 910 KSSLQENTFF 920 DDSLIDELLQ 930 QFANFGEVIL 940 IRFVEDKMWV 950 TFLEGSSALS 960 VLSLNGKELL 970 NRTITITLKS 980 PDWIRNLEEE 990 MSLEKISVTL 1000 PSSTSSTLLG 1010 EDAEVAADFD 1020 MEGDVDDYSA 1030 EVEELFPQHL 1040 QPSSSSGLGI 1050 SPGSSPRTSP 1060 CQSPTTAEAP 1070 VPSFPVRPSR 1080 APARTPGPPS 1090 SQSSPVDSQP 1100 VVQPQQKEPS 1110 QALEPKRPPP 1120 PRPVAPPTRP 1130 APPQRPPPPS 1140 GARSPAPARK 1150 EFGGAGAPPS 1160 PGVARREMEA 1170 PKSPGTTQKE 1180 NIGRSQPSPQ 1190 AGFAGPGPAG 1200 PSTVRPTIPP 1210 RAGVISAPQS 1220 HARVSTGRLT 1230 PESQSKPPES 1240 SKGSALLPEP 1250 LKPQAASPVQ 1260 SALPPPAQKL 1270 QEPLIPMTAP 1280 MPQPGPQPNL 1290 ETPPQPPPRS 1300 RSSHSLPSES 1310 SPQLQQEQPS G

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0030118	clathrin coat
Cellular Component	GO:0048471	perinuclear region of cytoplasm
Cellular Component	GO:0098793	presynapse
Molecular Function	GO:0004439	phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
Molecular Function	GO:0003723	RNA binding
Molecular Function	GO:0017124	SH3 domain binding
Biological Process	GO:0046856	phosphatidylinositol dephosphorylation
Biological Process	GO:0048259	regulation of receptor-mediated endocytosis
Biological Process	GO:0048488	synaptic vesicle endocytosis

Reference

[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.