Search Results
Overview
| Uniprot ID | H0VL10 |
|---|---|
| Protein Name | DNA repair protein XRCC4 |
| Gene Name | XRCC4 |
| Organism | Cavia porcellus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 277 | KRRQRMPKDVGSEAK |
| 297 | TPLPEKKKLDPARPE |
Function
Acts as an activator of the phospholipid scramblase activity of XKR4. This form, which is generated upon caspase-3 (CASP3) cleavage, translocates into the cytoplasm and interacts with XKR4, thereby promoting phosphatidylserine scramblase activity of XKR4 and leading to phosphatidylserine exposure on apoptotic cell surface
Protein Sequence
10
MERKISRICL
20
VSKPNVTHFL
30
QVSWEKSLES
40
GFVITLTDGQ
50
SAWIGTVSES
60
EIGQEADDMA
70
MEKEKYVGEL
80
RKALVSGAGT
90
GDAYKFDFSE
100
GDCCFSCEKN
110
LKDVSFRLGS
120
FNLEKVANPA
130
EVIRELLCYC
140
LDNIAENQAK
150
NEHLQKENER
160
LLRDWNDVQG
170
RFEKCVSAKE
180
DLETDLYKRF
190
ILVLNEKKSK
200
IRSLHKLLNE
210
VQELEKNIER
220
EREATASSET
230
PAARDPLYDA
240
STDEGSGSES
250
EPPASAPASL
260
NKEDSLISSP
270
DVTDVAPSRK
280
RRQRMPKDVG
290
SEAKVAPRGT
300
PLPEKKKLDP
310
ARPEMSEKEH
320
ISAENTSLET
CFKCLDSHQ
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005694 | chromosome |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0032807 | DNA ligase IV complex |
| Cellular Component | GO:0005958 | DNA-dependent protein kinase-DNA ligase 4 complex |
| Molecular Function | GO:0003677 | DNA binding |
| Biological Process | GO:0006303 | double-strand break repair via nonhomologous end joining |
| Biological Process | GO:0033152 | immunoglobulin V(D)J recombination |
| Biological Process | GO:0010165 | response to X-ray |
Reference
[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.