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Overview

Uniprot IDH0VL70
Protein NameLeucine--tRNA ligase, cytoplasmic
Gene NameLARS1
OrganismCavia porcellus

Kla Sites from experimental identification

Position Flanking peptide
968 NGRLPDNKLIASELG

Function

Aminoacyl-tRNA synthetase that catalyzes the specific attachment of leucine to its cognate tRNA (tRNA(Leu)). It performs tRNA aminoacylation in a two-step reaction: Leu is initially activated by ATP to form a leucyl-adenylate (Leu-AMP) intermediate; then the leucyl moiety is transferred to the acceptor 3' end of the tRNA to yield leucyl-tRNA. To improve the fidelity of catalytic reactions, it is also able to hydrolyze misactivated aminoacyl-adenylate intermediates (pre-transfer editing) and mischarged aminoacyl-tRNAs (post-transfer editing)

Protein Sequence

10 MAERKGTAKV 20 DFLKKIEKEI 30 QQKWEAEKVF 40 EVNASDLEKQ 50 SSKYFVTFPY 60 PYMNGRLHLG 70 HTFSLSKCEF 80 AVGYQRLKGK 90 CCLFPFGLHC 100 TGMPIKACAD 110 KLKREIELYG 120 CPPDFPDEEE 130 EEEEISVKTE 140 NTVVKDKAKG 150 KKSKAAAKAG 160 SSKYQWGIMQ 170 SLGLSDEEIV 180 KFSEAEHWLD 190 YFPPLAIQDL 200 KRIGLKVDWR 210 RSFITTDVNP 220 YYDSFVRWQF 230 LTLRERNKIK 240 FGKRYTIYSP 250 KDGQPCMDHD 260 RQTGEGVGPQ 270 EYTLLKLKVL 280 EPYPSKLSGL 290 KGKNIFLVAA 300 TLRPETMFGQ 310 TNCWVHPDIK 320 YIGFETVNGD 330 IFICTQRAAR 340 NMSYQGFTKD 350 NGVVPVVKEL 360 MGEEILGASL 370 SAPLTSYEVI 380 YLLPMLTIKE 390 EKGTGVVTSV 400 PSDSPDDVAA 410 LRDLKKKQAL 420 RAKYGIRDEM 430 VFPFEPVPVI 440 EIPGFGNLSA 450 VTICDELKIQ 460 SQNDREKLTE 470 AKEKLYLKGF 480 YEGIMLVDEF 490 KGQKVQDVKK 500 TIQKKMIDAG 510 DAYIYMEPEK 520 QVISRSSDEC 530 VVALCDQWYL 540 DYGEENWKKQ 550 TSQCLTNMET 560 FCEETRRNFE 570 ASLDWLQEHA 580 CSRTYGLGTR 590 LPWDEQWLIE 600 SLSDSTIYMA 610 FYTVAHLLQG 620 GNLHGQAESP 630 LGIRPQQLTK 640 EVWDYIFFKD 650 APFPQTQISK 660 EKLDQLKHEF 670 EFWYPVDLRV 680 SGKDLVPNHL 690 SYYLYNHVAM 700 WQEQSDKWPK 710 AVRANGHLLL 720 NSEKMSKSTG 730 NFLTLSQAVD 740 KFSADGMRLA 750 LADAGDTVED 760 ANFVEAMADA 770 GILRLYTWVE 780 WVKEMLANRD 790 SLRSGPANTF 800 NDRVFASEMN 810 AGIIKTDQNY 820 EKMMFKEALK 830 TGFFEFQAAK 840 DKYRELAIEG 850 MHRELVFRFI 860 EVQTLVLAPF 870 CPHLCEHIWT 880 LLGKSDSVMN 890 ASWPVAGPVD 900 EILIRSSQYL 910 MEVAHDLRLR 920 LKNYMVPAKG 930 KKTDQQPPQR 940 PSHCTIYVAK 950 DYPPWQHTTL 960 TFLRNHFEVN 970 NGRLPDNKLI 980 ASELGSMPEL 990 KKYMKKVMPF 1000 VAMVKENVEK 1010 MGPRVLDLQL 1020 EFDEQAVLME 1030 NAVYLTNSLE 1040 LEHIEVKFAS 1050 EADDKIREDC 1060 CPGKPLTVFR 1070 TEPGVPVSLV 1080 NPQPSNGHFS 1090 TKIEVRQGDN 1100 SDSIIRRLMK 1110 MDRGIKDLSQ 1120 VKLMRFDDPV 1130 LGPRRVPVLG 1140 KEHTEKTPIS 1150 EHAVFHVDLT 1160 SKKIHLTENG 1170 LRADIGDTII YLVH

Gene Ontology

Classification GO ID Description
Cellular Component GO:0017101 aminoacyl-tRNA synthetase multienzyme complex
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005783 endoplasmic reticulum
Cellular Component GO:0005764 lysosome
Molecular Function GO:0002161 aminoacyl-tRNA deacylase activity
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0004819 glutamine-tRNA ligase activity
Molecular Function GO:0005096 GTPase activator activity
Molecular Function GO:0004823 leucine-tRNA ligase activity
Biological Process GO:0071233 cellular response to L-leucine
Biological Process GO:1990253 cellular response to leucine starvation
Biological Process GO:0006425 glutaminyl-tRNA aminoacylation
Biological Process GO:0006429 leucyl-tRNA aminoacylation
Biological Process GO:1904263 positive regulation of TORC1 signaling

Reference

[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.