Search Results
Overview
| Uniprot ID | H0VL82 |
|---|---|
| Protein Name | Triosephosphate isomerase |
| Gene Name | TPI1 |
| Organism | Cavia porcellus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 14 | FFVGGNWKMNGRKNT |
| 142 | REAGITEKVVFEQTK |
| 149 | KVVFEQTKVISDNVK |
| 156 | KVISDNVKDWSKVVL |
| 19 | NWKMNGRKNTLGELI |
| 194 | EKLRGWLKSNVSDAV |
| 59 | ARQKLDPKIAVAAQN |
| 6 | **MAPSRKFFVGGNW |
Function
It is also responsible for the non-negligible production of methylglyoxal a reactive cytotoxic side-product that modifies and can alter proteins, DNA and lipids
Protein Sequence
10
MAPSRKFFVG
20
GNWKMNGRKN
30
TLGELINTLN
40
AAKVPADTEV
50
VCAPPTAYID
60
FARQKLDPKI
70
AVAAQNCYKV
80
TNGAFTGEIS
90
PGMIKDLGAT
100
WVVLGHSERR
110
HVFGESDELI
120
GQKVAHALAE
130
GLGVIACIGE
140
KLDEREAGIT
150
EKVVFEQTKV
160
ISDNVKDWSK
170
VVLAYEPVWA
180
IGTGKTATPQ
190
QAQEVHEKLR
200
GWLKSNVSDA
210
VAQSTRIIYG
220
GSVTGATCKE
230
LASQPDVDGF
240
LVGGASLKPE
FVDIINAKH
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Molecular Function | GO:0008929 | methylglyoxal synthase activity |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Molecular Function | GO:0004807 | triose-phosphate isomerase activity |
| Molecular Function | GO:0031625 | ubiquitin protein ligase binding |
| Biological Process | GO:0061621 | canonical glycolysis |
| Biological Process | GO:0006094 | gluconeogenesis |
| Biological Process | GO:0046166 | glyceraldehyde-3-phosphate biosynthetic process |
| Biological Process | GO:0019563 | glycerol catabolic process |
Reference
[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.