Overview
| Uniprot ID | H0VLD2 |
|---|
| Protein Name | High mobility group nucleosome-binding domain-containing protein 3 |
|---|
| Gene Name | HMGN3 |
|---|
| Organism | Cavia porcellus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 20 |
KEGSKVTKQEPTRRS |
Function
Binds to nucleosomes, regulating chromatin structure and consequently, chromatin-dependent processes such as transcription, DNA replication and DNA repair. Affects both insulin and glucagon levels and modulates the expression of pancreatic genes involved in insulin secretion. Regulates the expression of the glucose transporter SLC2A2 by binding specifically to its promoter region and recruiting PDX1 and additional transcription factors. Regulates the expression of SLC6A9, a glycine transporter which regulates the glycine concentration in synaptic junctions in the central nervous system, by binding to its transcription start site. May play a role in ocular development and astrocyte function
Protein Sequence
10
MPKRKSSENT
20
EGKEGSKVTK
30
QEPTRRSARL
40
STKPAPPKPE
50
PKPRKTAIKK
60
EPGTKINRGA
70
KGKKEEKQEA
80
GKEGTTPSEN
90
GETKAEEVLS
TVSR
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0000785 |
chromatin |
| Cellular Component |
GO:0005634 |
nucleus |
| Molecular Function |
GO:0031492 |
nucleosomal DNA binding |
| Biological Process |
GO:0006325 |
chromatin organization |
Reference
[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.