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Overview

Uniprot ID	H0VLN9
Protein Name	Eukaryotic translation initiation factor 3 subunit B
Gene Name	EIF3B
Organism	Cavia porcellus

Kla Sites from experimental identification

Position	Flanking peptide
234	ADGYKLDKQHTFRVN

Function

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome

Protein Sequence

10 MQDAENVAAP 20 EAAEERAEST 30 RQQPAGQPPP 40 EEESAGPGAP 50 ETARSEEAEE 60 EAAAGPEPEV 70 SAEPTEEAIS 80 GLAASPPPPP 90 TEELVPQSES 100 VSPGEQPREQ 110 CAEEAAGPEG 120 SAAEAAQRPV 130 ENGEADEPSF 140 SDPEDFVDDV 150 SEEELLGDIL 160 KDRPQEADGI 170 DSVIVVDNVP 180 QVGPDRLEKL 190 KNVIHKIFSK 200 FGKITNDYYP 210 EEDGKTKGYI 220 FLEYASPAHA 230 VDAVKNADGY 240 KLDKQHTFRV 250 NLFTDFDKYM 260 TISDEWDIPE 270 KQPFKDLGNL 280 RYWLEEAECR 290 DQYSVIFESG 300 DRTSIFWNDV 310 KDPVSIEERA 320 RWTETYVRWS 330 PKGTYLATFH 340 QRGIALWGGE 350 KFKQIQRFSH 360 QGVQLIDFSP 370 CERYLVTFSP 380 LMDTQDDPQA 390 IIIWDILTGH 400 KKRGFHCESS 410 AHWPIFKWSH 420 DGKFFARMTM 430 DTLSIYETPS 440 MGLLDKKSLK 450 ISGIKDFSWS 460 PGGNIIAFWV 470 PEDKDIPARV 480 TLMQLPSRQE 490 IRVRNLFNVV 500 DCKLHWQKNG 510 DYLCVKVDRT 520 PKGTQGVVTN 530 FEIFRMREKQ 540 VPVDVVEMKE 550 TIIAFAWEPN 560 GSKFAVLHGE 570 APRISVSFYH 580 VKNNGKIELI 590 KMFDKQQANT 600 IFWSPQGQFV 610 VLAGLRSMNG 620 ALAFVDTSDC 630 TVMNIAEHYM 640 ASDVEWDPTG 650 RYVVTSVSWW 660 SHKVDNAYWL 670 WTFQGRLLQK 680 NNKDRFCQLL 690 WRPRPPTLLS 700 QEQIKQIKKD 710 LKKYSKIFEQ 720 KDRLSQSKAS 730 KELVERRRTM 740 MEDFRKYRKM 750 AQERYMEQKN 760 ERLELRGGVD 770 TDELDSNVDD 780 WEEETIEFFV 790 TEEIIPLGNQ E

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0010494	cytoplasmic stress granule
Cellular Component	GO:0016282	eukaryotic 43S preinitiation complex
Cellular Component	GO:0033290	eukaryotic 48S preinitiation complex
Cellular Component	GO:0005852	eukaryotic translation initiation factor 3 complex
Molecular Function	GO:0003723	RNA binding
Molecular Function	GO:0003743	translation initiation factor activity
Molecular Function	GO:0031369	translation initiation factor binding
Biological Process	GO:0001732	formation of cytoplasmic translation initiation complex

Reference

[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.