Search Results
Overview
| Uniprot ID | H0VLR4 |
|---|---|
| Protein Name | Methyl-CpG-binding protein 2 |
| Gene Name | MECP2 |
| Organism | Cavia porcellus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 119 | KSGRSAGKYDVYLIN |
| 130 | YLINPQGKAFRSKVE |
| 200 | GSGSARPKAAASEGV |
| 210 | ASEGVQVKRVLEKSP |
| 215 | QVKRVLEKSPGKLLV |
| 219 | VLEKSPGKLLVKMPF |
| 22 | DQDLQSLKDKPLKFK |
| 233 | FQAAPGGKAEGGGAT |
| 249 | SAQVMVIKRPGRKRK |
| 256 | KRPGRKRKAEADPQA |
| 266 | ADPQAIPKKRGRKPG |
| 27 | SLKDKPLKFKKVKKD |
| 271 | IPKKRGRKPGSVVAA |
| 284 | AAAAAEAKKKAVKES |
| 289 | EAKKKAVKESSIRSV |
| 304 | QETVLPIKKRKTRET |
| 321 | IEVKEVVKPLIVSTL |
| 331 | IVSTLGEKSGKGLKT |
| 42 | KKEDKEAKHEPLQPS |
| 431 | LESDGCPKEPAKTQP |
| 435 | GCPKEPAKTQPVVPS |
| 467 | APAPATEKYKHRGEG |
| 477 | HRGEGERKDIVSSSM |
| 82 | PEASASPKQRRSIIR |
Function
Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC)
Protein Sequence
10
MVAGMLGLRE
20
EKSEDQDLQS
30
LKDKPLKFKK
40
VKKDKKEDKE
50
AKHEPLQPSA
60
HHSAEPAEAG
70
KAETSEGTGS
80
APAVPEASAS
90
PKQRRSIIRD
100
RGPMYDDPTL
110
PEGWTRKLKQ
120
RKSGRSAGKY
130
DVYLINPQGK
140
AFRSKVELIA
150
YFEKVGDTSL
160
DPNDFDFTVT
170
GRGSPSRREQ
180
RPPKKPKSPK
190
APGTGRGRGR
200
PKGSGSARPK
210
AAASEGVQVK
220
RVLEKSPGKL
230
LVKMPFQAAP
240
GGKAEGGGAT
250
TSAQVMVIKR
260
PGRKRKAEAD
270
PQAIPKKRGR
280
KPGSVVAAAA
290
AEAKKKAVKE
300
SSIRSVQETV
310
LPIKKRKTRE
320
TVSIEVKEVV
330
KPLIVSTLGE
340
KSGKGLKTCK
350
SPGRKSKESS
360
PKGRSSSASS
370
PPKKEHHHHH
380
HHMESPKAPA
390
PPLPPPPPPL
400
PEPESSEDPA
410
SPPEPQDLSG
420
SICKEEKMPR
430
GGALESDGCP
440
KEPAKTQPVV
450
PSAAPAPAAA
460
PAPAPAPALA
470
PAPATEKYKH
480
RGEGERKDIV
490
SSSMPRPNRE
500
EPVDSRTPVT
ERVS
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005813 | centrosome |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0000792 | heterochromatin |
| Cellular Component | GO:0005654 | nucleoplasm |
| Molecular Function | GO:0010385 | double-stranded methylated DNA binding |
| Molecular Function | GO:0140566 | histone reader activity |
| Molecular Function | GO:0008327 | methyl-CpG binding |
| Molecular Function | GO:0140693 | molecular condensate scaffold activity |
| Molecular Function | GO:0003729 | mRNA binding |
| Molecular Function | GO:1990841 | promoter-specific chromatin binding |
| Molecular Function | GO:0035197 | siRNA binding |
| Molecular Function | GO:0003714 | transcription corepressor activity |
| Biological Process | GO:0008306 | associative learning |
| Biological Process | GO:0048468 | cell development |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:0016525 | negative regulation of angiogenesis |
| Biological Process | GO:0043537 | negative regulation of blood vessel endothelial cell migration |
| Biological Process | GO:0044027 | negative regulation of gene expression via chromosomal CpG island methylation |
| Biological Process | GO:0051151 | negative regulation of smooth muscle cell differentiation |
| Biological Process | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| Biological Process | GO:0030182 | neuron differentiation |
| Biological Process | GO:0007219 | Notch signaling pathway |
| Biological Process | GO:0090063 | positive regulation of microtubule nucleation |
| Biological Process | GO:0043576 | regulation of respiratory gaseous exchange |
Reference
[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.