Search Results
Overview
| Uniprot ID | H0VLT4 |
|---|---|
| Protein Name | - |
| Gene Name | TMOD2 |
| Organism | Cavia porcellus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 101 | KGRVFIPKEKPVEPR |
Function
Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton
Protein Sequence
10
MALPFQKELE
20
KYKNLDEDEL
30
LGKLSAEELQ
40
QLENVLDDLD
50
PQSATLPAGL
60
RQKDQTQKAA
70
TGPFDREHLL
80
MYLEKEALEQ
90
KDREDFVPFT
100
GEKKGRVFIP
110
KEKPVEPRQE
120
EKVTLDPELE
130
EALAGASDTE
140
LYDLAAVLGV
150
HNLLNNPKFD
160
EETANGKGGK
170
GPVRNVVKGE
180
KVKPLFEEPP
190
NPTNVEVSLQ
200
QMKANDPSLQ
210
EVNLNNIKNI
220
PIPTLKDFAK
230
ALETNTHVKK
240
FSLAATRSND
250
PVAIAFADML
260
KVNRTLKSLN
270
IESNFITGSG
280
ILALVEALRE
290
NDSLTEIKID
300
NQRQQLGTAV
310
EMEIAQMLEE
320
NSRILKFGYQ
330
FTKQGPRTRV
340
AAAITKNNDL
350
VRKKRVEGDR
R
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005865 | striated muscle thin filament |
| Molecular Function | GO:0003779 | actin binding |
| Molecular Function | GO:0005523 | tropomyosin binding |
| Biological Process | GO:0007015 | actin filament organization |
| Biological Process | GO:0006936 | muscle contraction |
| Biological Process | GO:0030239 | myofibril assembly |
| Biological Process | GO:0051694 | pointed-end actin filament capping |
Reference
[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.