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Overview

Uniprot IDH0VLV9
Protein NameTranscription initiation factor IIF subunit alpha
Gene NameGTF2F1
OrganismCavia porcellus

Kla Sites from experimental identification

Position Flanking peptide
183 IMQQRRLKDQGQDEE
412 TLRAAASKLEQGKRT

Function

TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation

Protein Sequence

10 MATLGPGSQN 20 VTEYVVRVPK 30 NTTKKYNIMA 40 FNAADKVNFA 50 TWNQARLERD 60 LSNKKIYQEE 70 EMPESGAGSE 80 FNRKLREEAR 90 RKKYGIVLKE 100 FRPEDQPWLL 110 RVNGKSGRKF 120 KGIKKGGVTE 130 NTSYYIFTQC 140 PDGAFEAFPV 150 HNWYNFTPLA 160 RHRTLTAEEA 170 EEEWERRNKV 180 LNHFSIMQQR 190 RLKDQGQDEE 200 EEDKEKRSRE 210 KASGLRIHDL 220 EDDLEMSSDD 230 SEASGEEGSR 240 ASKTKKKAPL 250 TKAGRKKKKK 260 KKGSDDEAFE 270 DSDDGDFEGQ 280 EVDYMSDGSS 290 SSQDEPETGK 300 PKVQQQEEGP 310 KGVDEQSESS 320 EESEEEKPAA 330 AQEEDKEEEE 340 EKKAATPQEK 350 KRRKDSSDES 360 DSSEESDIDS 370 EASSALFMAK 380 KKTPPKRERK 390 PSGGSSRGNS 400 RPGSPGAEGG 410 NTSSTLRAAA 420 SKLEQGKRTS 430 ETPAAKRLRL 440 DAGPQSLSGK 450 STPQPPSGKS 460 TPSSGDVQVT 470 EDAVRRYLTR 480 KPMTTKDLLK 490 KFQTKKTGLS 500 SEQTVNVLAQ 510 ILKRLNPERK 520 MINDKMHFSL KE

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005669 transcription factor TFIID complex
Cellular Component GO:0005674 transcription factor TFIIF complex
Molecular Function GO:0003677 DNA binding
Molecular Function GO:0019211 phosphatase activator activity
Molecular Function GO:1990841 promoter-specific chromatin binding
Molecular Function GO:0019904 protein domain specific binding
Molecular Function GO:0019903 protein phosphatase binding
Molecular Function GO:0016251 RNA polymerase II general transcription initiation factor activity
Molecular Function GO:0001096 TFIIF-class transcription factor complex binding
Biological Process GO:0032968 positive regulation of transcription elongation by RNA polymerase II
Biological Process GO:0009615 response to virus
Biological Process GO:0006368 transcription elongation by RNA polymerase II
Biological Process GO:0006367 transcription initiation at RNA polymerase II promoter

Reference

[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.