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Overview

Uniprot IDH0VM26
Protein NameATP synthase subunit alpha
Gene NameATP5F1A
OrganismCavia porcellus

Kla Sites from experimental identification

Position Flanking peptide
505 GTIRADGKISEQSDA
513 ISEQSDAKLKEIVTN

Function

Produces ATP from ADP in the presence of a proton gradient across the membrane

Protein Sequence

10 MLSVRVAAAV 20 ARALPRRAGL 30 VSKNALGSSF 40 IAARNLHASN 50 TCLQKTGTAE 60 ITNLGADTSV 70 DLEETGRVLS 80 MAEENGRGMS 90 LNLEPDNVGV 100 VVFGNDKLIK 110 EGDIVKRTGA 120 IVDVPVGEEL 130 LGRVVDALGN 140 AIDGKGPIGS 150 KTRRRVGLKA 160 PGIIPRISVR 170 EPMQTGIKAV 180 DSLVPIGRGQ 190 RELIIGDRQT 200 GKTSIAIDTI 210 INQKRFNDGS 220 DEKKKLYCIY 230 VAIGQKRSTV 240 AQLVKRLTDA 250 DAMKYTIVVS 260 ATASDAAPLQ 270 YLAPYSGCSM 280 GEYFRDNGKH 290 ALIIYDDLSK 300 QAVAYRQMSL 310 LLRRPPGREA 320 YPGDVFYLHS 330 RLLERAAKMN 340 DAFGGGSLTA 350 LPVIETQAGD 360 VSAYIPTNVI 370 SITDGQIFLE 380 TELFYKGIRP 390 AINVGLSVSR 400 VGSAAQTRAM 410 KQVAGTMKLE 420 LAQYREVAAF 430 AQFGSDLDAA 440 TQQLLSRGVR 450 LTELLKQGQY 460 APMAIEEQVA 470 VIYAGVRGYL 480 DKLEPSKITK 490 FEQAFLSHVV 500 SQHQALLGTI 510 RADGKISEQS 520 DAKLKEIVTN FLAGFEA

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005743 mitochondrial inner membrane
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0045259 proton-transporting ATP synthase complex
Molecular Function GO:0043531 ADP binding
Molecular Function GO:0043532 angiostatin binding
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0042288 MHC class I protein binding
Molecular Function GO:0046933 proton-transporting ATP synthase activity, rotational mechanism
Biological Process GO:0001937 negative regulation of endothelial cell proliferation
Biological Process GO:0043536 positive regulation of blood vessel endothelial cell migration
Biological Process GO:0042776 proton motive force-driven mitochondrial ATP synthesis

Reference

[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.