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Overview

Uniprot ID	H0VM53
Protein Name	Long-chain-fatty-acid--CoA ligase
Gene Name	ACSL6
Organism	Cavia porcellus

Kla Sites from experimental identification

Position	Flanking peptide
560	DRKKHIFKLAQGEYV
674	GLLTPTLKAKRPELR

Function

Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation

Protein Sequence

10 MLTFFLVSGG 20 SLWLFAEFVL 30 SLLEKMQTQE 40 ILRILRLPEM 50 GDLGQFFRSL 60 SATTLVSMGA 70 LAAILAYWFT 80 HRPKALTPPC 90 NLLMQSEEVE 100 DGGGARRSVI 110 GGGPQLLTHY 120 YDDARTMYQV 130 FRRGLSISGN 140 GPCLGFRKPK 150 QPYQWLSYQE 160 VANRAEFLGS 170 GLLQHNCKAS 180 TDQFIGVFAQ 190 NRPEWIIAEL 200 ACYTYSMVVV 210 PLYDTLGPGA 220 IRYIINTADI 230 STVIVDKPQK 240 AVLLLEHVER 250 KDTPGLKLVL 260 LMEPFEEALK 270 ERGRKCGVVI 280 KSMQDVEDCG 290 QENHRAPVPP 300 QPDDLSIVCF 310 TSGTTGNPKG 320 AMLTHGNVVA 330 DFSGFLKVTE 340 SVVYCHGGRV 350 GFFQGDIRLL 360 SDDMKALRPT 370 IFPVVPRLLN 380 RMYDKIFSQA 390 DTALKRWLLE 400 FAAKRKQAEV 410 QSGIIRNNSI 420 WDELFFNKIQ 430 ASLGGRVRMI 440 VTGAAPASPT 450 VLGFLRAALG 460 CQVYEGYGQT 470 ECTAGCTFTT 480 PGDWTSGHVG 490 APLPCNHIKL 500 VDVEELNYWT 510 HKGEGEVCVK 520 GPNVFRGYLK 530 DQERTNEALD 540 SDGWLHTGDV 550 GKWLPEGTLK 560 IIDRKKHIFK 570 LAQGEYVAPE 580 KIENIYIRSE 590 PVAQIYVHGD 600 SLKAYLVGIV 610 VPDPEVMPSW 620 AQKRGIEGTY 630 AELCANKDLK 640 KAILEDLVRL 650 GKESGLHSFE 660 QVKAIHIHCD 670 MFSVQNGLLT 680 PTLKAKRPEL 690 REYFKKQIEE LYSVSM

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005789	endoplasmic reticulum membrane
Cellular Component	GO:0005741	mitochondrial outer membrane
Molecular Function	GO:0047676	arachidonate-CoA ligase activity
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0042803	protein homodimerization activity

Reference

[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.