Search Results
Overview
| Uniprot ID | H0VM62 |
|---|---|
| Protein Name | ATPase WRNIP1 |
| Gene Name | WRNIP1 |
| Organism | Cavia porcellus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 367 | SRKMFCKKSGQTYSP |
| 530 | NAPTRLMKDLGYGKG |
| 536 | MKDLGYGKGYKYNPM |
Function
Functions as a modulator of initiation or reinitiation events during DNA polymerase delta-mediated DNA synthesis. In the presence of ATP, stimulation of DNA polymerase delta-mediated DNA synthesis is decreased. Also plays a role in the innate immune defense against viruses. Stabilizes the RIGI dsRNA interaction and promotes RIGI 'Lys-63'-linked polyubiquitination. In turn, RIGI transmits the signal through mitochondrial MAVS
Protein Sequence
10
MEVSGPEDDP
20
FLSQLHQVQC
30
PRVPADDACR
40
AHQLSAAGPH
50
RAGERAKGPS
60
PPGAKRRRLS
70
ESSALKQPAT
80
PTAAESSEGE
90
GEEGDDGGET
100
ERHCDADAAD
110
TAFGTGGGSR
120
AHPRALAAEE
130
IRQMLEGKPL
140
ADKMRPDTLQ
150
DYIGQSRAVG
160
QETLLRPLLE
170
TNEIPSLILW
180
GPPGCGKTTL
190
AHIIANNSKK
200
HSIRFVTLSA
210
TNAKTNDVRD
220
VIKQAQNEKS
230
FFKRKTILFI
240
DEIHRFNKSQ
250
QDTFLPHVEC
260
GTLTLIGATT
270
ENPSFQVNAA
280
LLSRCRVIVL
290
EKLPVEAMVT
300
ILMRAINSLG
310
IHVLDSSRPG
320
DPLSHSSNSS
330
SEPSVFIEDK
340
AVDTLAYLSD
350
GDARTGLNGL
360
QLAVLARLSS
370
RKMFCKKSGQ
380
TYSPSRVLIT
390
ENDVKEGLQR
400
SHILYDRAGE
410
EHYNCISALH
420
KAMRGSDQNA
430
SLYWLARMLE
440
GGEDPLYVAR
450
RLVRFASEDI
460
GLADPSALTQ
470
AVAAYQGCHF
480
IGMPECEVLL
490
AQCVVYFARA
500
PKSIEVYSAY
510
NNVKACLRNH
520
QGPLPPVPLH
530
LRNAPTRLMK
540
DLGYGKGYKY
550
NPMYSEPVEQ
560
EYLPEELRGV
DFFKQRRC
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0000781 | chromosome, telomeric region |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0016887 | ATP hydrolysis activity |
| Molecular Function | GO:0003677 | DNA binding |
| Molecular Function | GO:0008047 | enzyme activator activity |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0017116 | single-stranded DNA helicase activity |
| Biological Process | GO:0000731 | DNA synthesis involved in DNA repair |
| Biological Process | GO:0006261 | DNA-templated DNA replication |
| Biological Process | GO:0045087 | innate immune response |
| Biological Process | GO:0030174 | regulation of DNA-templated DNA replication initiation |
Reference
[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.