Search Results

Overview

Uniprot IDH0VMF1
Protein NameMethionine--tRNA ligase, cytoplasmic
Gene NameMARS1
OrganismCavia porcellus

Kla Sites from experimental identification

Position Flanking peptide
866 MKAQKADKNLVAAEV

Function

Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. Plays a role in the synthesis of ribosomal RNA in the nucleolus

Protein Sequence

10 MRLFVSEGAP 20 GSLPVLVAAG 30 RAPGRSELLI 40 STVGPEECVV 50 PFLTQPKFPV 60 LQLDSGNYLF 70 STSAICRYFF 80 LLSGWEPDDF 90 TNQWLEWEAT 100 ELQPVLSAAL 110 YYLVIQGKKG 120 EDVLDPLGKA 130 LTHIDHSLSR 140 QNCPFLGGET 150 ESLADVVLWG 160 ALYPLLQDPA 170 YLPEELGALR 180 SWFQTLSTQE 190 PCQRAAETVL 200 KQKGVLALRP 210 YLQKQPQPSL 220 PEGRAVSNEP 230 EEEELATLSE 240 EEIAAAVTAW 250 KKGLEGLPVL 260 RPQQNPVLPV 270 AGERNVLITS 280 ALPYVNNVPH 290 LGNIIGCVLS 300 ADVFARYSRL 310 RQWNTLYLCG 320 TDEYGTATET 330 KAMEEGLTPQ 340 EICDKYHTIH 350 ADIYRWFNIS 360 FDFFGRTTTP 370 QQTKITQDIF 380 HRLLTRGFIL 390 EDTVEQLRCE 400 HCARFLADRF 410 VEGVCPFCGY 420 EEARGDQCDK 430 CGKLINAIEL 440 KKPQCKVCRS 450 CPVVKSSRHL 460 FLDLPKLEKR 470 LEEWLGKTLP 480 GSDWTPNARF 490 IIRSWLRDGL 500 KPRCITRDLK 510 WGTPVPLEGF 520 EDKVFYVWFD 530 ATIGYLSITA 540 NYTDQWEKWW 550 KNPEQVDLYQ 560 FMAKDNVPFH 570 GLVFPCSALG 580 TDDNYTLVKY 590 LIATEYLNYE 600 DGKFSKSRGV 610 GVFGDMAQDT 620 GIPADIWRFY 630 LLYIRPEGQD 640 SAFSWTDMLL 650 KNNSELLNNL 660 GNFINRAGMF 670 VSKFFGGYVP 680 EMVLTPDDQR 690 LLTHITLELQ 700 HYHQLLEKVR 710 IRDALRSILT 720 VSRHGNQYIQ 730 VNEPWKRIKG 740 NEADRQRAGT 750 VTGMAVNIAA 760 LLSVMLQPYM 770 PTVSATIQAQ 780 LQLPLPACSV 790 LPTDFLCTLP 800 AGHQIGIVSP 810 LFQKLENDQI 820 ESLKQHFGGS 830 QAKVSPNPAA 840 IETVTTPGPQ 850 QIQMLMAEVT 860 KQGNIVREMK 870 AQKADKNLVA 880 AEVAKLLDLK 890 KQLALTEGKP 900 LETLKGKKKK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0017101 aminoacyl-tRNA synthetase multienzyme complex
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005730 nucleolus
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0004825 methionine-tRNA ligase activity
Molecular Function GO:0000049 tRNA binding
Biological Process GO:0071364 cellular response to epidermal growth factor stimulus
Biological Process GO:0036120 cellular response to platelet-derived growth factor stimulus
Biological Process GO:0050667 homocysteine metabolic process
Biological Process GO:0006431 methionyl-tRNA aminoacylation
Biological Process GO:1901838 positive regulation of transcription of nucleolar large rRNA by RNA polymerase I
Biological Process GO:0009303 rRNA transcription

Reference

[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.