Search Results
Overview
| Uniprot ID | H0VMM0 |
|---|---|
| Protein Name | Malonate--CoA ligase ACSF3, mitochondrial |
| Gene Name | ACSF3 |
| Organism | Cavia porcellus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 488 | IIKTGGYKVSALEVE |
| 568 | IPRNQMGKINKKDLV |
Function
Catalyzes the initial reaction in intramitochondrial fatty acid synthesis, by activating malonate and methylmalonate, but not acetate, into their respective CoA thioester. May have some preference toward very-long-chain substrates
Protein Sequence
10
MLVGAMLPRG
20
TVAFRRLACT
30
MASCRPAPRR
40
HRGHGLLHTA
50
TTARSGAAAP
60
VFTQAPGFGD
70
RVALIDQHGC
80
HTYRDLYLRS
90
LHLSQEILRL
100
RGCVDGDLQD
110
ERVSFLCSND
120
VSYVVAQWAS
130
WMSGGIAVPL
140
FPKHPPAQLE
150
YFIEDSRSSV
160
VLAGPEHVQL
170
VGPVAERLGV
180
PLLSLPPTVY
190
QGAAGEPAAV
200
APVQERKWQD
210
RGAMIIYTSG
220
TTGRPKGVLS
230
THRNLTAMVT
240
GLVHAWAWTR
250
DDVILHVLPL
260
HHMHGVVNKL
270
LCPLWVGATC
280
MMLPEFSAQQ
290
VWEKFLSLET
300
PRVNVFMAVP
310
TIYSKLLDYY
320
DQHFTQPHVR
330
DFVRAICEEK
340
IRLMVSGSAA
350
LPVPLLERWK
360
RATSHTLLER
370
YGMTEVGMAL
380
SSPLAGPRLP
390
GSVGTPLPKV
400
EVRIVSESPQ
410
RNGCPYTVHA
420
EGDAQGTKVT
430
PGLEEKEGEL
440
LVRGPSVFRE
450
YWDKPEETKC
460
AFTPDGWFRT
470
GDTAVFKDGS
480
YWIRGRTSVD
490
IIKTGGYKVS
500
ALEVERHLLA
510
HPSIADVAVI
520
GIPDMTWGQR
530
VTAVVALKAG
540
RSLSHSELKH
550
WARHFLAPYA
560
VPSELLLVEE
570
IPRNQMGKIN
580
KKDLVRQFFP
590
ESGQGPAPTM
DQGPAPSG
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0090409 | malonyl-CoA synthetase activity |
| Molecular Function | GO:0031956 | medium-chain fatty acid-CoA ligase activity |
| Molecular Function | GO:0031957 | very long-chain fatty acid-CoA ligase activity |
| Biological Process | GO:0006633 | fatty acid biosynthetic process |
| Biological Process | GO:0090410 | malonate catabolic process |
Reference
[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.