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Overview

Uniprot IDH0VN78
Protein NamePHD finger protein 6
Gene NamePHF6
OrganismCavia porcellus

Kla Sites from experimental identification

Position Flanking peptide
26 FCKSNRDKECGQLLI

Function

Transcriptional regulator that associates with ribosomal RNA promoters and suppresses ribosomal RNA (rRNA) transcription

Protein Sequence

10 MSSSIEQKKG 20 PTRQRKCGFC 30 KSNRDKECGQ 40 LLISENQKVA 50 AHHKCMLFSS 60 ALVSSHSDNE 70 SLGGFSIEDV 80 QKEIKRGTKL 90 MCSLCHCPGA 100 TIGCDVKTCH 110 RTYHYHCALH 120 DKAQIREKPS 130 QGIYMVYCRK 140 HKKTTHNSEA 150 DLEESFNEHE 160 LEPSSPKSKK 170 KSRKGRPRKT 180 NFKGLSEDTR 190 STSSHGTDEM 200 ESSSYRDRSP 210 HRSSPSDTRP 220 KCGFCHVGEE 230 ENEARGKLHI 240 FNAKKAAAHY 250 KCMLFSSGTV 260 QLTTTSRAEF 270 GDFDIKTVLQ 280 EIKRGKRMKC 290 TLCSQPGATI 300 GCEIKACVKT 310 YHYHCGVQDK 320 AKYIENMSRG 330 IYKLYCKNHS 340 GNDERDEEDE 350 ERESKSRGKV 360 EIDQQQAQQQ LNGN

Gene Ontology

Classification GO ID Description
Cellular Component GO:0000776 kinetochore
Cellular Component GO:0005730 nucleolus
Cellular Component GO:0005654 nucleoplasm
Molecular Function GO:0003677 DNA binding
Molecular Function GO:0042393 histone binding
Molecular Function GO:0042826 histone deacetylase binding
Molecular Function GO:0051219 phosphoprotein binding
Molecular Function GO:0043021 ribonucleoprotein complex binding
Molecular Function GO:0097110 scaffold protein binding
Molecular Function GO:0015631 tubulin binding
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II

Reference

[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.