Search Results
Overview
| Uniprot ID | H0VP63 |
|---|---|
| Protein Name | Zinc finger CCCH domain-containing protein 14 |
| Gene Name | ZC3H14 |
| Organism | Cavia porcellus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 126 | ISSTRPEKRDSRVAA |
| 490 | PNCKYDAKCTKPDCP |
Function
RNA-binding protein involved in the biogenesis of circular RNAs (circRNAs), which are produced by back-splicing circularization of pre-mRNAs. Acts by binding to both exon-intron boundary and 3'-UTR of pre-mRNAs to promote circRNA biogenesis through dimerization and the association with the spliceosome. Required for spermatogenesis via involvement in circRNA biogenesis. Regulates the pre-mRNA processing of ATP5MC1; preventing its degradation. Also binds the poly(A) tail of mRNAs; controlling poly(A) length in neuronal cells
Protein Sequence
10
MEIGTEISRK
20
IRSAIKGKLQ
30
ELGAYVDEEL
40
PDYIMVMVAN
50
KKSQDQMTED
60
LSLFLGNNTI
70
RFTVWLHGVL
80
DKLRSVTTEP
90
SSLKSSDTNI
100
FDNNVPSNKS
110
SFSRGDERRH
120
EATVPPLAIS
130
STRPEKRDSR
140
VAASSQEQKT
150
SNLRQTYDDG
160
AATRLMSTVK
170
PLREPAPSED
180
VIDIKPEPDD
190
LIDEDLNFVP
200
ENPLSQKKPT
210
VTLTYGSSRP
220
SIEIYRPPAS
230
RNAESSAHLN
240
RLQFQQQQNS
250
IHAAKQLDMQ
260
NSRVYETEHT
270
CEPEVLNSLE
280
ETYSPFFRNN
290
SEKMMIEEEN
300
FRKRKLPVVS
310
SVVKVKKFNH
320
DGEEEEEDDD
330
YGSRTGSVSS
340
SVSVPAKPER
350
RPSLPPSKQA
360
NKNLILKAIS
370
EAQESVTKTT
380
NYSAVPQKQT
390
LPVAPRTRTS
400
QEELLAEVVQ
410
GQSRTSRVSP
420
PIKEEETKGD
430
NAEKNQVEMS
440
ELNVAQKPEK
450
LLERCKYWPA
460
CKNGDECAYH
470
HPVSPCKAFP
480
NCKFAEKCLF
490
VHPNCKYDAK
500
CTKPDCPFTH
510
INRRIPVLPP
520
KPVTTTASPS
530
TSQLCRYFPA
540
CKKMECPFYH
550
PKHCRFNTQC
560
TRPDCTFYHP
570
TITVPPRHAL
KWIRPQTSE
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0016607 | nuclear speck |
| Molecular Function | GO:0008143 | poly(A) binding |
| Molecular Function | GO:0008270 | zinc ion binding |
| Biological Process | GO:0030154 | cell differentiation |
| Biological Process | GO:0043488 | regulation of mRNA stability |
| Biological Process | GO:0007283 | spermatogenesis |
Reference
[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.