Search Results
Overview
| Uniprot ID | H0VQ41 |
|---|---|
| Protein Name | Protein arginine N-methyltransferase 5 |
| Gene Name | PRMT5 |
| Organism | Cavia porcellus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 240 | TSIFLTNKKGFPVLS |
Function
Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA)
Protein Sequence
10
MAAMAVGGAG
20
GSRVSSGRDL
30
NCVPEIADTL
40
GAVAKQGFDF
50
LCMPVFHPRF
60
KREFTQEPAK
70
NRPGPQTRSD
80
LLLSGRDWNT
90
LIVGKLSPWI
100
HPDSKVEKIR
110
RNSEAAMLQE
120
LNFGAYLGLP
130
AFLLPLNQED
140
NTNLARVLTN
150
HIHTGHHSSM
160
FWMRVPLVAP
170
EDLRDDIIEN
180
VPTTHTQEYS
190
GEEKTWMWWH
200
NFRTLCDYSK
210
RIAVALEIGA
220
DLPSNHVIDR
230
WLGEPIKAAI
240
LPTSIFLTNK
250
KGFPVLSKMH
260
QRLIFRLLKL
270
EVQFIITGTN
280
HHSEKEFCSY
290
LQYLEYLSQN
300
RPPPNAYELF
310
AKGYEDYLQS
320
PLQPLMDNLE
330
SQTYEVFEKD
340
PIKYSQYQQA
350
IYKCLLDRVP
360
EEEKDTNVQV
370
LMVLGAGRGP
380
LVNASLRAAK
390
QADRRIKLYA
400
VEKNPNAVVT
410
LENWQFEEWG
420
SQVTVVSSDM
430
REWVAPEKAD
440
IIVSELLGSF
450
ADNELSPECL
460
DGAQHFLKDD
470
GVSIPGEYTS
480
FLAPISSSKL
490
YNEVRACREK
500
DRDPEAQFEM
510
PYVVRLHNFH
520
QLSAPQPCFT
530
FSHPNRDPMI
540
DNNRYCTLEF
550
PVEVNTVLHG
560
FAGYFETVLY
570
QDITLSIRPE
580
THSPGMFSWF
590
PILFPIKQPI
600
TVREGQTICV
610
RFWRCSSSKK
620
VWYEWAVTAP
630
VCSAIHNPTG
RSYTIGL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0000785 | chromatin |
| Biological Process | GO:0090161 | Golgi ribbon formation |
| Biological Process | GO:0032259 | methylation |
| Biological Process | GO:1904992 | positive regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway |
| Biological Process | GO:0006355 | regulation of DNA-templated transcription |
| Biological Process | GO:0000387 | spliceosomal snRNP assembly |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005794 | Golgi apparatus |
| Cellular Component | GO:0035097 | histone methyltransferase complex |
| Cellular Component | GO:0034709 | methylosome |
| Molecular Function | GO:0044020 | histone H4R3 methyltransferase activity |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0008327 | methyl-CpG binding |
| Molecular Function | GO:0002039 | p53 binding |
| Molecular Function | GO:0046982 | protein heterodimerization activity |
| Molecular Function | GO:0035243 | protein-arginine omega-N symmetric methyltransferase activity |
| Molecular Function | GO:0043021 | ribonucleoprotein complex binding |
| Biological Process | GO:0006353 | DNA-templated transcription termination |
| Biological Process | GO:0042118 | endothelial cell activation |
Reference
[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.