Search Results

Overview

Uniprot IDH0VQ72
Protein NameMatrin-3
Gene NameMATR3
OrganismCavia porcellus

Kla Sites from experimental identification

Position Flanking peptide
3 *****MSKSFQQSSL
487 PEGKPDQKFDQKQEL
491 PDQKFDQKQELGRVI
554 AMVDHCLKKALWFQG
555 MVDHCLKKALWFQGR
836 KLKKFLNKLAEERRQ

Function

May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the SFPQ-NONO heteromer may play a role in nuclear retention of defective RNAs. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway. Binds to N6-methyladenosine (m6A)-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs. May bind to specific miRNA hairpins

Protein Sequence

10 MSKSFQQSSL 20 GRDSQGHGRD 30 LSAAGIGLLA 40 AATQSLSMPA 50 SLGRMNQGTA 60 RLASLMNLGM 70 SSSLNQQGAH 80 SALSSASTSS 90 HNLQSIFNIG 100 SRGPLPLSSQ 110 HRGDADQASN 120 ILASFGLSAR 130 DLDELSRYPE 140 DKITPENLPQ 150 ILLQLKRRRT 160 EEGPTLSYGR 170 DGRSATREPP 180 YRVPRDDWEE 190 KRHFRRDSFD 200 DRGPSLNPVL 210 DYDHGSRSQE 220 SGYYDRMDYE 230 DDRLRDGERC 240 RDDSFFGETS 250 HNYHKFDSEY 260 ERMGRGPGPL 270 QERSLFEKKR 280 GAPPSSNIED 290 FHGLLPKGYP 300 HLCSICDLPV 310 HSNKEWSQHI 320 NGASHSRRCQ 330 LLLEIYPEWN 340 PDNDTGHTMG 350 DPFMLQQSTN 360 PAPGILGPPP 370 PSFHLGGPAV 380 GPRGNLGAGN 390 GNLQGPRHMQ 400 KGRVETSRVV 410 HIMDFQRGKN 420 LRYQLLQLVE 430 PFGVISNHLI 440 LNKINEAFIE 450 MATTEDAQAA 460 VDYYTTTPAL 470 VFGKPVRVHL 480 SQKYKRIKKP 490 EGKPDQKFDQ 500 KQELGRVIHL 510 SNLPHSGYSD 520 SAVLKLAEPY 530 GKIKNYILMR 540 MKSQAFIEME 550 TREDAMAMVD 560 HCLKKALWFQ 570 GRCVKVDLSE 580 KYKKLVLRIP 590 NRGIDLLKKD 600 KSRKRSYSPD 610 GKESPSDKKS 620 KTDGSQKTES 630 TAEGKEQEEK 640 SGEDAEKDTK 650 DDQTEQEPNM 660 LLESEDELLV 670 DEEEAAALLE 680 SGSSVGDDTD 690 LANLGDVASD 700 GKKETSDKAI 710 KKDASASAAA 720 KKKLKKVDKI 730 EELDQDNEAA 740 LENGIKNEEN 750 TEPGAESAEN 760 ADDPNKDTSE 770 NADGQSDENK 780 DDFTIPDEYR 790 IGPYQPNVPV 800 GIDYVIPKTG 810 FYCKLCSLFY 820 TNEEVAKNTH 830 CSSLPHYQKL 840 KKFLNKLAEE RRQKKEG

Gene Ontology

Classification GO ID Description
Cellular Component GO:0016363 nuclear matrix
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0035198 miRNA binding
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0002218 activation of innate immune response
Biological Process GO:0045087 innate immune response
Biological Process GO:0010608 post-transcriptional regulation of gene expression

Reference

[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.