Overview
| Uniprot ID | H0VQC2 |
|---|
| Protein Name | Peroxiredoxin-1 |
|---|
| Gene Name | PRDX1 |
|---|
| Organism | Cavia porcellus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 190 |
TIKPDVQKSKEYFSK |
| 192 |
KPDVQKSKEYFSKQK |
| 197 |
KSKEYFSKQK***** |
| 35 |
DISLSDYKGKYIVFF |
| 7 |
*MSSGNAKIGHPAPN |
| 93 |
AWINTPKKQGGLGPM |
Function
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2). Reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation
Protein Sequence
10
MSSGNAKIGH
20
PAPNFKATAV
30
MPDGQFKDIS
40
LSDYKGKYIV
50
FFFYPLDFTF
60
VCPTEIIAFS
70
DRAEEFKKLN
80
CQVIGASVDS
90
HFCHLAWINT
100
PKKQGGLGPM
110
NIPLVSDPKR
120
TIAQDYGVLK
130
ADEGISFRGL
140
FIIDDKGILR
150
QITVNDLPVG
160
RSVDETLRLV
170
QAFQFTDKHG
180
EVCPAGWKPG
190
SDTIKPDVQK
SKEYFSKQK
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0005634 |
nucleus |
| Molecular Function |
GO:0042802 |
identical protein binding |
| Molecular Function |
GO:0008379 |
thioredoxin peroxidase activity |
| Biological Process |
GO:0045454 |
cell redox homeostasis |
| Biological Process |
GO:0042744 |
hydrogen peroxide catabolic process |
| Biological Process |
GO:0030101 |
natural killer cell activation |
| Biological Process |
GO:0019430 |
removal of superoxide radicals |
Reference
[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.