Search Results
Overview
| Uniprot ID | H0VQQ0 |
|---|---|
| Protein Name | DNA mismatch repair protein |
| Gene Name | MSH2 |
| Organism | Cavia porcellus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 537 | EKVLRNNKNFSTVDI |
Function
Component of the post-replicative DNA mismatch repair system (MMR)
Protein Sequence
10
MAVQPKETLQ
20
LESVAEAGFV
30
RFFQAMPEKP
40
TTTVRLFDRG
50
DFYTAHGEDA
60
LLAAREVFKT
70
QGVIKYLGPA
80
GAKTLQSVVL
90
SKMNFESFVK
100
DLLLVRQYRV
110
EVYKNKAGNK
120
ASKENDWYLA
130
FKASPGNLSQ
140
FEDILFGNND
150
MAASIGVVGI
160
KMSAVDGQRQ
170
VGVGYVDSAQ
180
RKLGLCEFPD
190
NDQFSNLEAL
200
LIQIGPKECV
210
LPGGETAGDM
220
GKLRQIIQRA
230
GILITERKRA
240
EFSTKDIYQD
250
LNRLLKGKKG
260
EQMNSAVLPE
270
MENQVAVSSL
280
SAVIKFLDLL
290
SDDSNFGQFE
300
LTTFDFSQYM
310
KLDIAAVKAL
320
NLFQGSVEDT
330
TGSQSLAALL
340
NKCKTPQGQR
350
LVHQWIKQPL
360
MDKNRIEERL
370
NLVEAFVEDA
380
ELRQSLQEDL
390
LRRFPDLNRL
400
AKKFQRQAAN
410
LQDCYRLYQG
420
INQLPNVIQA
430
LEKYEGRHQA
440
LLLAVFAAPL
450
VDLRSDFSKF
460
QEMIETTLDM
470
DQVENHEFLV
480
KPSFDPNLSE
490
LREVMDDLEK
500
KMQSTLISAA
510
RDLGLDPGKQ
520
IKLDSSAQFG
530
YYFRVTCKEE
540
KVLRNNKNFS
550
TVDIQKNGVK
560
FTNSKLSSLN
570
EEYTKNKGEY
580
EEAQDAIVKE
590
IVNISSGYVE
600
PMQSLNDVLA
610
QLDAVVSFAH
620
VSNGAPVPYV
630
RPVILEKGQG
640
RIILKASRHA
650
CVEVQDEVAF
660
IPNDVHFEKD
670
KQMFHIITGP
680
NMGGKSTYIR
690
QTGVIVLMAQ
700
IGCFVPCESA
710
EVSIVDCILA
720
RVGAGDSQLK
730
GVSTFMAEML
740
ETASILRSAT
750
KDSLIIIDEL
760
GRGTSTYDGF
770
GLAWAISDYI
780
ATRIGAFCMF
790
ATHFHELTAL
800
ANQIPTVNNL
810
HVTALTTAET
820
LTMLYQVKKG
830
VCDQSFGIHV
840
AELANFPRHV
850
VECAKQKALE
860
LEEFQSIGAS
870
QGCNDREPAA
880
KKCYLEREQG
890
ERIIQEFLTK
900
VKQVPFTEMS
910
EESITKKLKQ
920
LKAEVMAQNN
930
SFVNEIISRI
KVTT
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005694 | chromosome |
| Cellular Component | GO:0032301 | MutSalpha complex |
| Cellular Component | GO:0032302 | MutSbeta complex |
| Cellular Component | GO:0005654 | nucleoplasm |
| Molecular Function | GO:0043531 | ADP binding |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0016887 | ATP hydrolysis activity |
| Molecular Function | GO:0140664 | ATP-dependent DNA damage sensor activity |
| Molecular Function | GO:0019237 | centromeric DNA binding |
| Molecular Function | GO:0003682 | chromatin binding |
| Molecular Function | GO:0032181 | dinucleotide repeat insertion binding |
| Molecular Function | GO:0008047 | enzyme activator activity |
| Molecular Function | GO:0000400 | four-way junction DNA binding |
| Molecular Function | GO:0032137 | guanine/thymine mispair binding |
| Molecular Function | GO:0000287 | magnesium ion binding |
| Molecular Function | GO:0032405 | MutLalpha complex binding |
| Molecular Function | GO:0032357 | oxidized purine DNA binding |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Molecular Function | GO:0032142 | single guanine insertion binding |
| Molecular Function | GO:0032143 | single thymine insertion binding |
| Molecular Function | GO:0003697 | single-stranded DNA binding |
| Biological Process | GO:0006301 | DNA damage tolerance |
| Biological Process | GO:0007276 | gamete generation |
| Biological Process | GO:0043570 | maintenance of DNA repeat elements |
| Biological Process | GO:0006298 | mismatch repair |
| Biological Process | GO:0006312 | mitotic recombination |
| Biological Process | GO:0045910 | negative regulation of DNA recombination |
| Biological Process | GO:0048298 | positive regulation of isotype switching to IgA isotypes |
| Biological Process | GO:0048304 | positive regulation of isotype switching to IgG isotypes |
| Biological Process | GO:0002204 | somatic recombination of immunoglobulin genes involved in immune response |
Reference
[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.