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Overview

Uniprot IDH0VRD6
Protein NameSplicing factor 3A subunit 1
Gene NameSF3A1
OrganismCavia porcellus

Kla Sites from experimental identification

Position Flanking peptide
424 GEKIPASKMQEHMRI
533 IEAIHKAKGLVPEDD
702 EEFLRRNKGPVSIKV

Function

Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs. The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing. Within the 17S U2 SnRNP complex, SF3A1 is part of the SF3A subcomplex that contributes to the assembly of the 17S U2 snRNP, and the subsequent assembly of the pre-spliceosome 'E' complex and the pre-catalytic spliceosome 'A' complex. Involved in pre-mRNA splicing as a component of pre-catalytic spliceosome 'B' complexes

Protein Sequence

10 MPAGPVQAVP 20 PPPPVITEPK 30 QPTEEEGSSK 40 EDSTPSKPVV 50 GIIYPPPEVR 60 NIVDKTASFV 70 ARNGPEFEAR 80 IRQNEINNPK 90 FNFLNPNDPY 100 HAYYRHKVSE 110 FKEGKAQEPS 120 AAIPKVMQQQ 130 QQAAQQQLPQ 140 KVQAQVIQET 150 IVPKEPPPEF 160 EFIADPPSIS 170 AFDLDVVKLT 180 AQFVARNGRQ 190 FLTQLMQKEQ 200 RNYQFDFLRP 210 QHSLFNYFTK 220 LVEQYTKILI 230 PPKGLFTKLK 240 KEAENPREVL 250 DQVCYRVEWA 260 KFQERERKKE 270 EEEKEKERVA 280 YAQIDWHDFV 290 VVETVDFQPN 300 EQGNFPPPTT 310 PEELGARILI 320 QERYEKFGES 330 EEVEMEVESD 340 EEDEKQEKSE 350 ETPSQLDQDT 360 QVQDMDEGSD 370 DEEEGQKVPP 380 PPETPMPPPL 390 PPTPDQVIVR 400 KDYDPKASKP 410 LPPAPAPDEY 420 LVSPITGEKI 430 PASKMQEHMR 440 IGLLDPRWLE 450 QRDRSIREKQ 460 SDDEVYAPGL 470 DIESSLKQLA 480 ERRTDIFGVE 490 ETAIGKKIGE 500 EEIQKPEEKV 510 TWDGHSGSMA 520 RTQQAAQANI 530 TLQEQIEAIH 540 KAKGLVPEDD 550 TKEKIGPSKP 560 NEIPQQPPPP 570 SSATNIPSSA 580 PPITSVPRPP 590 AMPPPVRTTV 600 VSAVPVMPRP 610 PMASVVRLPP 620 GSVIAPMPPI 630 IHAPRINVVP 640 MPPSAPPIMA 650 PRPPPMIVPT 660 AFVPAPPVAP 670 VPAPAPMPPV 680 HPPPPMEDEP 690 ASKKLKTEDS 700 LMPEEEFLRR 710 NKGPVSIKVQ 720 VPNMQDKTEW 730 KLNGQVLVFT 740 LPLTDQVSVI 750 KVKIHEATGM 760 PAGKQKLQYE 770 GIFIKDSNSL 780 AYYNMANGAV 790 IHLALKERGG RKK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0071013 catalytic step 2 spliceosome
Cellular Component GO:0016607 nuclear speck
Cellular Component GO:0005686 U2 snRNP
Cellular Component GO:0071005 U2-type precatalytic spliceosome
Cellular Component GO:0071004 U2-type prespliceosome
Molecular Function GO:0003723 RNA binding
Biological Process GO:0045292 mRNA cis splicing, via spliceosome
Biological Process GO:0000381 regulation of alternative mRNA splicing, via spliceosome
Biological Process GO:1903241 U2-type prespliceosome assembly

Reference

[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.