Search Results
Overview
| Uniprot ID | H0VRZ2 |
|---|---|
| Protein Name | U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase |
| Gene Name | METTL16 |
| Organism | Cavia porcellus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 5 | ***MALSKSMHARNR |
Function
RNA N6-methyltransferase that methylates adenosine residues at the N(6) position of a subset of RNAs and is involved in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts. Able to N6-methylate a subset of mRNAs and U6 small nuclear RNAs (U6 snRNAs). In contrast to the METTL3-METTL14 heterodimer, only able to methylate a limited number of RNAs: requires both a 5'UACAGAGAA-3' nonamer sequence and a specific RNA structure
Protein Sequence
10
MALSKSMHAR
20
NRYKDKPPDF
30
AYLASKYPDF
40
KQHVQINLNG
50
RVSLNFKDPE
60
AVRALTCTLL
70
KEDFGLSIDI
80
PLERLIPTVP
90
LRLNYIHWVE
100
DLIGHQDADK
110
TPLRRGIDIG
120
TGASCIYPLL
130
GATLNGWYFL
140
ATEVDDMCFN
150
YAKKNVEQNN
160
LSDLIKVVKV
170
PQKTLLMDAL
180
KEESEIIYDF
190
CMCNPPFFAN
200
QLEAKGVNSR
210
NSRRPPPSSV
220
NTGGITEIMA
230
EGGELEFVKR
240
IIHDSLQLKK
250
RLRWYSCMLG
260
KKCSLAPLKE
270
ELRIQGVPKV
280
TFTEFCQGRT
290
MRWALAWSFY
300
DDVTVPSPPS
310
KRRKLEKPRK
320
PITFVVLESV
330
MKELSLKASS
340
LGSETVEGIV
350
VVTTWIEKIL
360
TDLKVQHKRV
370
PCGKEEISLF
380
LTAIENSWIH
390
LRRKKRERVR
400
QLREVPRAPE
410
DVIQALEEKK
420
ATSKESGSSQ
430
DVALIPQESA
440
LCGPPLREEE
450
SATVGGLCPA
460
QELFSQEETP
470
EPLEDEMSEE
480
KGGTEVVESC
490
KGSSNGAQDQ
500
EADKGKHLQG
510
AGAQYLFKCL
520
INVKKEVDDA
530
LVEMHWVEGQ
540
NRDLMNQLCT
550
YIRNQIFRLV
AS
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Biological Process | GO:1905869 | negative regulation of 3'-UTR-mediated mRNA stabilization |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005654 | nucleoplasm |
| Molecular Function | GO:0001734 | mRNA m(6)A methyltransferase activity |
| Molecular Function | GO:0035613 | RNA stem-loop binding |
| Molecular Function | GO:0120048 | U6 snRNA (adenine-(43)-N(6))-methyltransferase activity |
| Molecular Function | GO:0030629 | U6 snRNA 3'-end binding |
| Biological Process | GO:0006402 | mRNA catabolic process |
| Biological Process | GO:0061157 | mRNA destabilization |
| Biological Process | GO:0006397 | mRNA processing |
| Biological Process | GO:0048024 | regulation of mRNA splicing, via spliceosome |
| Biological Process | GO:0070475 | rRNA base methylation |
| Biological Process | GO:0120049 | snRNA (adenine-N6)-methylation |
Reference
[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.