Search Results
Overview
| Uniprot ID | H0VS05 |
|---|---|
| Protein Name | APC membrane recruitment protein 2 |
| Gene Name | AMER2 |
| Organism | Cavia porcellus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 373 | RTPGSLLKDSKIPIS |
| 412 | RTKIPVSKVLVRRVS |
Function
Negative regulator of the canonical Wnt signaling pathway involved in neuroectodermal patterning. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex
Protein Sequence
10
MDSHCDCAAE
20
PPAAEPPPSG
30
KINKAAFKLF
40
KKRKSGGTMP
50
SIFGVKNKGD
60
AKSSAPTTTT
70
TTTTGMVRSR
80
THDGLAEVVV
90
LEGGRKEEPR
100
GPNPGPPRAA
110
APGPGSLAAG
120
SVAKSHSFFS
130
LLRKNGRPEP
140
GKGDPADASR
150
AGGKQKRGLR
160
GIFSRMRWPR
170
KDRPVTSRPP
180
GRASPRRPKK
190
TPGGVVVYQG
200
GGEEMASPEG
210
VDDTCLQEFW
220
DMLSQAEDQG
230
QAPPEAAVAK
240
AAPAQEAKAV
250
PETSRDARAA
260
EAPRDASSVK
270
RRRLHGVPAE
280
LHPKEEPQPS
290
EKEPPEGVPN
300
SDQGYWDSTT
310
PGPEEDAGAG
320
GGKRSGLPRD
330
SDSGDALYDL
340
YAEPDASPAG
350
PPAGEETACL
360
SRLKPVSPGA
370
ITCPLRTPGS
380
LLKDSKIPIS
390
IKHLSNLPSS
400
HPATHQQPAK
410
SELRRTKIPV
420
SKVLVRRVSN
430
RGLAGTTLRA
440
AALHDSAKKL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005886 | plasma membrane |
| Molecular Function | GO:0008013 | beta-catenin binding |
| Molecular Function | GO:0005546 | phosphatidylinositol-4,5-bisphosphate binding |
| Biological Process | GO:0090090 | negative regulation of canonical Wnt signaling pathway |
| Biological Process | GO:0016055 | Wnt signaling pathway |
Reference
[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.