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Overview

Uniprot ID	H0VS82
Protein Name	Dihydropyrimidinase-related protein 4
Gene Name	DPYSL4
Organism	Cavia porcellus

Kla Sites from experimental identification

Position	Flanking peptide
512	ARASCPGKISVPPVR

Function

Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration

Protein Sequence

10 SDRLLIKGGK 20 IVNDDQSFYA 30 DLYVEDGLIK 40 QIGENLIVPG 50 GIKTIDAHGL 60 MVLPGGVDVH 70 TRLQMPVLGM 80 TPADDFCQGT 90 KAALAGGTTM 100 ILDHVFPDTG 110 VSLLAAYEQW 120 REKADSMACC 130 DYSLHVDIPR 140 WHESIKEELE 150 ALVKDKGTSS 160 GVLGHFWSRC 170 GPTDMGPMYE 180 IFSIIRDLGA 190 LAQVHAENGD 200 IVEEEQKRLL 210 ERGITGPEGH 220 VLSHPEEVEA 230 EAVYRAVTIA 240 KQANCPLYIT 250 KVMSKGAADV 260 VAQAKRRGVV 270 VFGEPITASL 280 GADGSHYWSK 290 NWAKAAAFVT 300 SPPINPDPST 310 TDHLTSLLSS 320 GDLQVTGSAH 330 CTFTTAQKAV 340 GKDNFTLIPE 350 GTNGVEERMS 360 VVWEKCVASG 370 KMDENEFVAV 380 TSTNAAKIFN 390 FYPRKGRIAV 400 GSDADLVIWN 410 PRATKIISAK 420 THNVNVEYNI 430 FEGVECRGSP 440 TVVISQGRVV 450 LEGGNLFAIP 460 GSGRFIPRKT 470 FPDFVYKRIK 480 ARNRLAEIHG 490 VPRGLYDGPV 500 HEVMVPTKPG 510 SGTQARASCP 520 GKISVPPVRN 530 LHQSGFSLSG 540 SQADDHIARR 550 TAQKIMAPPG GRSNITSLS

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005829	cytosol
Molecular Function	GO:0016812	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides

Reference

[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.