Search Results
Overview
| Uniprot ID | H0VS89 |
|---|---|
| Protein Name | Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial |
| Gene Name | SUCLA2 |
| Organism | Cavia porcellus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 102 | VLAGGRGKGTFESGL |
Function
ATP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. Also able to act as an ATP-specific itaconyl- and malyl-CoA synthetase
Protein Sequence
10
MAALLASPSL
20
RSHRPRTALR
30
AAAQVLGSSG
40
LFNNHGLQIQ
50
QQQQRNLSLH
60
EYMSMELLQE
70
AGVSIPKGYV
80
AKSADEAYAI
90
AKKLGSKDVV
100
IKAQVLAGGR
110
GKGTFESGLK
120
GGVKIVFSPE
130
EAKAVSSQMI
140
GKKLFTKQTG
150
AKGRICNQVL
160
ICERKYPRRE
170
YYFAITMERS
180
FQGPVLIGSS
190
QGGVNIEDVA
200
AETPDAIVKE
210
PVDIVEGIKK
220
EQAVQLATKM
230
GFPANIVDSA
240
AENMVKLYNL
250
FLKYDATMVE
260
INPMVEDSDG
270
AVLCMDAKIN
280
FDSNSAYRQK
290
KIFDLQDWTQ
300
EDERDRDAAK
310
ANLNYIGLDG
320
NIGCLVNGAG
330
LAMATMDIIK
340
LHGGTPANFL
350
DVGGGATVQQ
360
VTEAFKLITS
370
DKKVLAILVN
380
IFGGIMRCDV
390
IAQGIVMAVK
400
DLEIKIPVVV
410
RLQGTRVDDA
420
KALIADSGLK
430
ILACDDLDEA
440
AKMVVKLSEI
450
VTLAKQAHVD
VKFQLPI
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0009361 | succinate-CoA ligase complex (ADP-forming) |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0000287 | magnesium ion binding |
| Molecular Function | GO:0004775 | succinate-CoA ligase (ADP-forming) activity |
| Biological Process | GO:0006108 | malate metabolic process |
| Biological Process | GO:0006104 | succinyl-CoA metabolic process |
| Biological Process | GO:0110052 | toxic metabolite repair |
| Biological Process | GO:0006099 | tricarboxylic acid cycle |
Reference
[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.