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Overview

Uniprot IDH0VSJ5
Protein NameSolute carrier family 12 member 5
Gene NameSLC12A5
OrganismCavia porcellus

Kla Sites from experimental identification

Position Flanking peptide
1032 KVHLTWTKDKSAAEK
1041 KSAAEKNKGPSPVSS

Function

Mediates electroneutral potassium-chloride cotransport in mature neurons and is required for neuronal Cl(-) homeostasis. As major extruder of intracellular chloride, it establishes the low neuronal Cl(-) levels required for chloride influx after binding of GABA-A and glycine to their receptors, with subsequent hyperpolarization and neuronal inhibition. Involved in the regulation of dendritic spine formation and maturation

Protein Sequence

10 MSRRFTVTSL 20 PPAAPAATPD 30 PESRRHSVAD 40 PRYLPGEDGK 50 GDGNPKESSP 60 FINSTDTEKG 70 KEYDGKNMAL 80 FEEEMDTSPM 90 VSSLLSGLAN 100 YTNLPQGSRE 110 HEEAENNEGG 120 KKKPVQAPRM 130 GTFMGVYLPC 140 LQNIFGVILF 150 LRLTWVVGIA 160 GIMESFCMVF 170 ICCSCTMLTA 180 ISMSAIATNG 190 VVPAGGSYYM 200 ISRSLGPEFG 210 GAVGLCFYLG 220 TTFAGAMYIL 230 GTIEILLAYL 240 FPAMAIFKAE 250 DASGEAAAML 260 NNMRVYGTCV 270 LTCMATVVFV 280 GVKYVNKFAL 290 VFLGCVILSI 300 LAIYAGVIKS 310 AFDPPNFPIC 320 LLGNRTLSRH 330 GFDVCAKLAW 340 EGNETVTTRL 350 WGLFCSSRFL 360 NATCDEYFTR 370 NNVTEIQGIP 380 GAASGLIKEN 390 LWSSYLTKGV 400 IVERRGMPSV 410 GLPDGTPIDM 420 DHPYVFSDMT 430 SYFTLLVGIY 440 FPSVTGIMAG 450 SNRSGDLRDA 460 QKSIPTGTIL 470 AIATTSAVYI 480 SSVVLFGACI 490 EGVVLRDKFG 500 EAVNGNLVVG 510 TLAWPSPWVI 520 VIGSFFSTCG 530 AGLQSLTGAP 540 RLLQAISRDG 550 IVPFLQVFGH 560 GKANGEPTWA 570 LLLTAGICEI 580 GILIASLDEV 590 APILSMFFLM 600 CYMFVNLACA 610 VQTLLRTPNW 620 RPRFRYYHWT 630 LSFLGMSLCL 640 ALMFICSWYY 650 ALVAMLIAGL 660 IYKYIEYRGA 670 EKEWGDGIRG 680 LSLSAARYAL 690 LRLEEGPPHT 700 KNWRPQLLVL 710 VRVDQDQNVV 720 HPQLLSLTSQ 730 LKAGKGLTIV 740 GSVLEGTFLD 750 NHPQAQRAEE 760 SIRRLMEAEK 770 VKGFCQVVIS 780 SNLRDGVSHL 790 IQSGGLGGLQ 800 HNTVLVGWPR 810 NWRQKEDHQT 820 WRNFIELVRE 830 TTAGHLALLV 840 TKNVAMFPGN 850 PERFSEGSID 860 VWWIVHDGGM 870 LMLLPFLLRH 880 HKVWRKCKMR 890 IFTVAQMDDN 900 SIQMKKDLTT 910 FLYHLRITAE 920 VEVVEMHESD 930 ISAYTYEKTL 940 VMEQRSQILK 950 QMHLTKNERE 960 REIQSITDES 970 RGSIRRKNPA 980 NTRLRLNVPE 990 ETAGDGEEKP 1000 EEEVQLIHDQ 1010 SAPSCPSSSP 1020 SPGEEPGEGE 1030 TDPEKVHLTW 1040 TKDKSAAEKN 1050 KGPSPVSSEG 1060 IKDFFSMKPN 1070 QSNVRRMHTA 1080 VRLNEVIVNK 1090 SRDAKLVLLN 1100 MPGPPRNRNG 1110 DENYMEFLEV 1120 LTEHLDRVML 1130 VRGGGREVIT IYS

Gene Ontology

Classification GO ID Description
Cellular Component GO:0030425 dendrite
Cellular Component GO:0043025 neuronal cell body
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0045202 synapse
Molecular Function GO:0046872 metal ion binding
Molecular Function GO:0015379 potassium:chloride symporter activity
Biological Process GO:0006884 cell volume homeostasis
Biological Process GO:0007268 chemical synaptic transmission
Biological Process GO:0055064 chloride ion homeostasis
Biological Process GO:0032502 developmental process
Biological Process GO:0055075 potassium ion homeostasis
Biological Process GO:1990573 potassium ion import across plasma membrane

Reference

[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.