Search Results

Overview

Uniprot IDH0VSR2
Protein NameZinc finger protein 521
Gene NameZNF521
OrganismCavia porcellus

Kla Sites from experimental identification

Position Flanking peptide
194 DHLKIHLKTHTSNKP

Function

Transcription factor that can both act as an activator or a repressor depending on the context. Involved in BMP signaling and in the regulation of the immature compartment of the hematopoietic system. Associates with SMADs in response to BMP2 leading to activate transcription of BMP target genes. Acts as a transcriptional repressor via its interaction with EBF1, a transcription factor involved specification of B-cell lineage; this interaction preventing EBF1 to bind DNA and activate target genes

Protein Sequence

10 MSRRKQAKPR 20 SLKDPNCKLE 30 DKTEDGEAID 40 CKKRPEDGEE 50 LEDEAAHSCD 60 SCLQVFESLS 70 DITEHKINQC 80 QLTDGVDVED 90 DPTCSWPASS 100 PSSKDQTSPS 110 HGEGCDFGEE 120 EGGPGLPYPC 130 QFCDKSFSRL 140 SYLKHHEQSH 150 SDKLPFKCTY 160 CSRLFKHKRS 170 RDRHIKLHTG 180 DKKYHCSECD 190 AAFSRSDHLK 200 IHLKTHTSNK 210 PYKCAICRRG 220 FLSSSSLHGH 230 MQVHERNKDG 240 SQSGSRMEDW 250 KMKDTQKCSQ 260 CEEGFDFPED 270 LQKHIAECHP 280 ECSPNEDRAA 290 LQCVYCHELF 300 VEETSLMNHM 310 EQVHGGEKKN 320 SCSICSESFH 330 TVEELYSHMD 340 SHQQPESCNH 350 SNSPSLVTVG 360 YTSVSSTTPD 370 SNLSVDSSTM 380 VETAPPIPKS 390 RGRKRAAQQT 400 PDMTGPSGKQ 410 PKVTYSCIYC 420 NKQLFSSLAV 430 LQIHLKTMHL 440 DKPEQAHICQ 450 YCLEVLPSLY 460 NLNEHLKQVH 470 EAQDPGLIVS 480 AMPAIVYQCN 490 FCSEVVNDLN 500 TLQEHIRCSH 510 GFANPAAKES 520 NAFFCPHCYM 530 GFLTDSSLEE 540 HIRQVHCDLS 550 GSRFGSPVLG 560 TPKEPVVEVY 570 SCSYCTNSPI 580 FNSVLKLNKH 590 IKENHKNIPL 600 ALNYIHNGKK 610 SRALSPLSPV 620 AIEQTSLKMM 630 QAVGGAPARP 640 AGEYICNQCG 650 AKYTSLDSFQ 660 THLKTHLDTV 670 LPKLTCPQCN 680 KEFPNQESLL 690 KHVTIHFMIT 700 STYYICESCD 710 KQFTSVDDLQ 720 KHLLDMHTFV 730 FFRCTLCQEV 740 FDSKVSIQLH 750 LAVKHSNEKK 760 VYRCTSCNWD 770 FRNETDLQLH 780 VKHNHLENQG 790 KVHKCIFCGE 800 SFGTEVELQC 810 HITTHSKKYN 820 CKFCSKAFHA 830 IILLEKHLRE 840 KHCVFETKAP 850 NCGTNGASEQ 860 VQKEEVELQT 870 LLTNSQESHN 880 SHDGSEEDVD 890 SSEPMYGCDI 900 CGAAYTMETL 910 LQNHQLRDHN 920 IRPGESAIVK 930 KKAELIKGNY 940 KCNVCSRTFF 950 SENGLREHMQ 960 THLGPVKHYM 970 CPICGERFPS 980 LLTLTEHKVT 990 HSKSLDTGNC 1000 RICKMPLQSE 1010 EEFLEHCQMH 1020 PDLRNSLTGF 1030 RCVVCMQTVT 1040 STLELKIHGT 1050 FHMQKTGNGS 1060 AVQATGRGQH 1070 VQKLYKCASC 1080 LKEFRSKQDL 1090 VKLDINGLPY 1100 GLCAGCVNLS 1110 KSSSPGISLP 1120 PSTNRPGLGQ 1130 NENLSAMEGK 1140 GKTGALKTRC 1150 SSCNVKFESE 1160 SELQNHIQTV 1170 HRELVPDGNS 1180 TQLKTPQVSP 1190 MPRISPSQSD 1200 EKKTYQCIKC 1210 QMVFYNEWDI 1220 QVHVANHMID 1230 EGLNHECKLC 1240 SQTFDSPAKL 1250 QCHLIEHSFE 1260 GMGGTFKCPV 1270 CFTVFVQANK 1280 LQQHIFSAHG 1290 QEDKIYDCTQ 1300 CPQKFFFQTE 1310 LQNHTMTQHS S

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005654 nucleoplasm
Molecular Function GO:0003677 DNA binding
Molecular Function GO:0019904 protein domain specific binding
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0030154 cell differentiation
Biological Process GO:0006351 DNA-templated transcription

Reference

[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.