Search Results
Overview
| Uniprot ID | H0VT92 |
|---|---|
| Protein Name | Integrin-linked kinase-associated serine/threonine phosphatase 2C |
| Gene Name | ILKAP |
| Organism | Cavia porcellus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 272 | EERMRIQKAGGNVRD |
| 80 | EGTGAKRKASEGEDG |
Function
Protein phosphatase that may play a role in regulation of cell cycle progression via dephosphorylation of its substrates whose appropriate phosphorylation states might be crucial for cell proliferation. Selectively associates with integrin linked kinase (ILK), to modulate cell adhesion and growth factor signaling. Inhibits the ILK-GSK3B signaling axis and may play an important role in inhibiting oncogenic transformation
Protein Sequence
10
MDLFGDLPEP
20
ERSPHAAAGK
30
DAPKGSLLFD
40
GLPPASSTDS
50
GSAGPLLFDD
60
LPPAGSGKSG
70
SLTASVSQLA
80
KNEGTGAKRK
90
ASEGEDGSGE
100
LVEKKVCKGS
110
SVIFGLKGYV
120
AERKGEREEM
130
QDAHVILNDI
140
TEECNPPSSL
150
ITRVSYFAVF
160
DGHGGIRASK
170
FAAQNLHQNL
180
IRKFPKGDVV
190
SVEKTVKRCL
200
LDTFKHTDEE
210
FLKQASSQKP
220
AWKDGSTATC
230
VLAVDNTLYI
240
ANLGDSRAIL
250
CRYNEESQKH
260
AALSLSKEHN
270
PTQYEERMRI
280
QKAGGNVRDG
290
RVLGVLEVSR
300
SIGDGQYKRC
310
GVTSVPDIRR
320
CQLTPNDRFI
330
LLACDGLFKV
340
FTPEEAVNFI
350
LSCLEDEKIQ
360
TREGKPAVDA
370
RYEAACNRLA
380
NKAVQRGSAD
390
NVTVMVVQIG
H
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0004722 | protein serine/threonine phosphatase activity |
Reference
[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.