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Overview

Uniprot IDH0VTB2
Protein NameDNA topoisomerase 2
Gene NameTOP2B
OrganismCavia porcellus

Kla Sites from experimental identification

Position Flanking peptide
1203 ILAGMSGKAIKGKVG
1216 VGKPKVKKLQLEETM
141 GIPVVEHKVEKVYVP
1478 QTDKVPSKTVAAKKG
1484 SKTVAAKKGKPPLDI
1536 GRGAKKRKASGSENE
356 EVVKKKNKAGVSVKP
428 ILNWVKFKAQTQLNK

Function

Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand

Protein Sequence

10 IVFNSLACSD 20 GATLFDQNNA 30 AKKEESETAN 40 KNDSSKKLSV 50 ERVYQKKTQL 60 EHILLRPDTY 70 IGSVEPLTQM 80 MWVYDDDVGM 90 NCREVTFVPG 100 LYKIFDEILV 110 NAADNKQRDK 120 NMTCIKVSID 130 PESNIISIWN 140 NGKGIPVVEH 150 KVEKVYVPAL 160 IFGQLLTSSN 170 YDDDEKKVTG 180 GRNGYGAKLC 190 NIFSTKFTVE 200 TACKEYKHSF 210 KQTWMNNMMK 220 TSEAKIKHFD 230 GEDYTCITFQ 240 PDLSKFKMEK 250 LDKDIVALMT 260 RRAYDLAGSC 270 KGVKVMFNGK 280 KLPVNGFRSY 290 VDLYVKDKLD 300 ETGVALKVIH 310 ELANERWDVC 320 LTLSEKGFQQ 330 ISFVNSIATT 340 KGGRHVDYVV 350 DQVVGKLIEV 360 VKKKNKAGVS 370 VKPFQVKNHI 380 WVFINCLIEN 390 PTFDSQTKEN 400 MTLQPKSFGS 410 KCQLSEKFFK 420 AASNCGIVES 430 ILNWVKFKAQ 440 TQLNKKCSSV 450 KYSKIKGIPK 460 LDDANDAGGK 470 HSLECTLILT 480 EGDSAKSLAV 490 SGLGVIGRDR 500 YGVFPLRGKI 510 LNVREASHKQ 520 IMENAEINNI 530 IKIVGLQYKK 540 SYDDAESLKT 550 LRYGKIMIMT 560 DQDQDGSHIK 570 GLLINFIHHN 580 WPSLLKHGFL 590 EEFITPIVKA 600 SKNKQELSFY 610 SIPEFDEWKK 620 HIENQKAWKI 630 KYYKGLGTST 640 AKEAKEYFAD 650 MERHRILFRY 660 AGPEDDAAIT 670 LAFSKKKIDD 680 RKEWLTNFME 690 DRRQRRLHGL 700 PEQFLYGTAT 710 KHLTYNDFIN 720 KELILFSNSD 730 NERSIPSLVD 740 GFKPGQRKVL 750 FTCFKRNDKR 760 EVKVAQLAGS 770 VAEMSAYHHG 780 EQALMMTIVN 790 LAQNFVGSNN 800 INLLQPIGQF 810 GTRLHGGKDA 820 ASPRYIFTML 830 SSLARLLFPA 840 VDDNLLKFLY 850 DDNQRVEPEW 860 YIPIIPMVLI 870 NGAEGIGTGW 880 ACKLPNYDAR 890 EIVNNVRRML 900 EGLDPHPMLP 910 NYKNFKGTIQ 920 ELGQNQYAVS 930 GEIFVVDRNT 940 VEITELPVRT 950 WTQVYKEQVL 960 EPMLNGTDKT 970 PALISDYKEY 980 HTDTTVKFVV 990 KMTEEKLAQA 1000 EAAGLHKVFK 1010 LQTTLTCNSM 1020 VLFDHMGCLK 1030 KYETVQDILK 1040 EFFDLRLSYY 1050 GLRKEWLVGM 1060 LGAESAKLNN 1070 QARFILEKIQ 1080 GKITIENRSK 1090 KDLIQMLVQR 1100 GYESDPVKAW 1110 KEAQEKAAEE 1120 EETQNQHDDS 1130 SSDSGTPSGP 1140 DFNYILNMSL 1150 WSLTKEKVEE 1160 LIKQRDAKGR 1170 EVNDLKRKSP 1180 SDLWKEDLAA 1190 FVEELDKVEA 1200 QEREDILAGM 1210 SGKAIKGKVG 1220 KPKVKKLQLE 1230 ETMPSPYGRR 1240 IIPEITAMKA 1250 DASKKLLKKK 1260 KGDLDTTVVK 1270 VEFDEEFSGT 1280 PVEGTGEEAL 1290 APSAPISKGP 1300 KPKREKKEPG 1310 TRVRKTPTAS 1320 GKPSAKKVKK 1330 RNPWSDDESK 1340 SESDLEETEP 1350 VVIPRDSLLR 1360 RAAAERPKYT 1370 FDFSEEDDDD 1380 ADDDDDNNDL 1390 EELKVKASPI 1400 TNDGEDEFIP 1410 SDGLDKDEYT 1420 FSASKSKTTP 1430 EKSSHEKKSQ 1440 DFGNLFSFPS 1450 YSQKSEDDSA 1460 KFDSNEEDTA 1470 SVFSPSFGLK 1480 QTDKVPSKTV 1490 AAKKGKPPLD 1500 IASKPKRAPK 1510 QKKVVETVNS 1520 DSDSEFGIPK 1530 KTAAPKGKGR 1540 GAKKRKASGS 1550 ENEGDYNPGR 1560 KTSKTTSKKP 1570 KKTSFDQDSD 1580 VDIFPSDFTS 1590 DPPSLPRTGR 1600 ARKEVKYFAE 1610 SDEEEDVDFA MFN

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005730 nucleolus
Cellular Component GO:0005654 nucleoplasm
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0003677 DNA binding
Molecular Function GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
Molecular Function GO:0046872 metal ion binding
Biological Process GO:0006265 DNA topological change
Biological Process GO:0000712 resolution of meiotic recombination intermediates
Biological Process GO:0000819 sister chromatid segregation

Reference

[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.