Search Results
Overview
| Uniprot ID | H0VTR5 |
|---|---|
| Protein Name | DNA excision repair protein ERCC-1 |
| Gene Name | ERCC1 |
| Organism | Cavia porcellus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 40 | PGAKPLFKSTRSFPN |
Function
Non-catalytic component of a structure-specific DNA repair endonuclease responsible for the 5'-incision during DNA repair. Responsible, in conjunction with SLX4, for the first step in the repair of interstrand cross-links (ICL). Participates in the processing of anaphase bridge-generating DNA structures, which consist in incompletely processed DNA lesions arising during S or G2 phase, and can result in cytokinesis failure. Also required for homology-directed repair (HDR) of DNA double-strand breaks, in conjunction with SLX4
Protein Sequence
10
MDPEKDEEGT
20
PKPAGPPSRK
30
KFVIPLDQDE
40
VPPGAKPLFK
50
STRSFPNVET
60
SETSAQSAPQ
70
SYAEYAISRP
80
TVGAAATCHT
90
GSEPLAGETP
100
NQALKPGAKS
110
NSIIVSPRQR
120
GNPVLKFVRN
130
VPWEFGEVIP
140
DYVLGQSTCA
150
LFLSLRYHNL
160
HPDYIHERLQ
170
SLGKNFALRI
180
LLVQVDVKDP
190
QQALKELAKM
200
CILADCTLIL
210
AWSPEEAGRY
220
LETYKAYEQK
230
PADLLMEKLE
240
QNFVSRITEC
250
LTTVKSVNKT
260
DSQTLLSTFG
270
SLEQLMAASR
280
QDLALCPGLG
290
PQKARRLFDV
300
LHEPFLKVPR
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0000781 | chromosome, telomeric region |
| Cellular Component | GO:0070522 | ERCC4-ERCC1 complex |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0000110 | nucleotide-excision repair factor 1 complex |
| Molecular Function | GO:1990599 | 3' overhang single-stranded DNA endodeoxyribonuclease activity |
| Molecular Function | GO:0003684 | damaged DNA binding |
| Molecular Function | GO:1990841 | promoter-specific chromatin binding |
| Molecular Function | GO:0003697 | single-stranded DNA binding |
| Molecular Function | GO:0001094 | TFIID-class transcription factor complex binding |
| Biological Process | GO:0006303 | double-strand break repair via nonhomologous end joining |
| Biological Process | GO:1905765 | negative regulation of protection from non-homologous end joining at telomere |
| Biological Process | GO:0006289 | nucleotide-excision repair |
| Biological Process | GO:1904431 | positive regulation of t-circle formation |
| Biological Process | GO:0006979 | response to oxidative stress |
| Biological Process | GO:0090656 | t-circle formation |
| Biological Process | GO:0061819 | telomeric DNA-containing double minutes formation |
| Biological Process | GO:0070914 | UV-damage excision repair |
Reference
[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.