Search Results

Overview

Uniprot IDH0VTY8
Protein NameElongation factor 2
Gene NameEEF2
OrganismCavia porcellus

Kla Sites from experimental identification

Position Flanking peptide
239 YVAKFAAKGEGQLGP
439 PNYTPGKKEDLYLKP

Function

Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome

Protein Sequence

10 MVNFTVDQIR 20 AIMDKKANIR 30 NMSVIAHVDH 40 GKSTLTDSLV 50 CKAGIIASAR 60 AGETRFTDTR 70 KDEQERCITI 80 KSTAISLFYE 90 LSENDLNFIK 100 QSKDGSGFLI 110 NLIDSPGHVD 120 FSSEVTAALR 130 VTDGALVVVD 140 CVSGVCVQTE 150 TVLRQAIAER 160 IKPVLMMNKM 170 DRALLELQLE 180 PEELYQTFQR 190 IVENVNVIIS 200 TYGEGESGPM 210 GNIMIDPVLG 220 TVGFGSGLHG 230 WAFTLKQFAE 240 MYVAKFAAKG 250 EGQLGPAERA 260 KKVEDMMKKL 270 WGDRYFDPAS 280 GKFSKSATSP 290 DGKKLPRTFC 300 QLILDPIFKV 310 FDAIMNFRKE 320 ETAKLIEKLD 330 IKLDSEDKDK 340 EGKPLLKAVM 350 RRWLPAGDAL 360 LQMITIHLPS 370 PVTAQKYRCE 380 LLYEGPPDDE 390 AAMGIKSCDP 400 KGPLMMYISK 410 MVPTSDKGRF 420 YAFGRVFSGL 430 VSTGLKVRIM 440 GPNYTPGKKE 450 DLYLKPIQRT 460 ILMMGRYVEP 470 IEDVPCGNIV 480 GLVGVDQFLV 490 KTGTITTFEH 500 AHNMRVMKFS 510 VSPVVRVAVE 520 AKNPADLPKL 530 VEGLKRLAKS 540 DPMVQCIIEE 550 SGEHIIAGAG 560 ELHLEICLKD 570 LEEDHACIPI 580 KKSDPVVSYR 590 ETVSEESNVM 600 CLSKSPNKHN 610 RLYMKARPFP 620 DGLAEDIDKG 630 EVSARQELKQ 640 RARYLAEKYE 650 WDVAEARKIW 660 CFGPDGTGPN 670 ILTDITKGVQ 680 YLNEIKDSVV 690 AGFQWATKEG 700 ALCEENMRDP 710 IYLVEIQCPE 720 QVVGGIYGVL 730 NRKRGHVFEE 740 SQVAGTPMFV 750 VKAYLPVNES 760 FGFTADLRSN 770 TGGQAFPQCV 780 FDHWQILPGD 790 PFDSSSRPSQ 800 VVAETRKRKG 810 LKEGIPALDN FLDKL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005634 nucleus
Cellular Component GO:1990904 ribonucleoprotein complex
Cellular Component GO:0005840 ribosome
Cellular Component GO:0045202 synapse
Molecular Function GO:0005525 GTP binding
Molecular Function GO:0003924 GTPase activity
Molecular Function GO:0106222 lncRNA binding
Molecular Function GO:0019901 protein kinase binding
Molecular Function GO:0043022 ribosome binding
Molecular Function GO:0003746 translation elongation factor activity
Biological Process GO:0045727 positive regulation of translation

Reference

[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.