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Overview

Uniprot ID	H0VVE1
Protein Name	Zinc finger protein 281
Gene Name	Znf281
Organism	Cavia porcellus

Kla Sites from experimental identification

Position	Flanking peptide
381	SRRKSKSKSIPIENK

Function

Transcription repressor that plays a role in regulation of embryonic stem cells (ESCs) differentiation. Required for ESCs differentiation and acts by mediating autorepression of NANOG in ESCs: binds to the NANOG promoter and promotes association of NANOG protein to its own promoter and recruits the NuRD complex, which deacetylates histones. Not required for establishement and maintenance of ESCs. Represses the transcription of a number of genes including GAST, ODC1 and VIM. Binds to the G-rich box in the enhancer region of these genes

Protein Sequence

10 MKIGSGFLSG 20 GGGTGSSGSS 30 GPGCGSSGPG 40 SGGSRRAEME 50 PTFPQGMVMF 60 NHRLPPVTSF 70 TRPAGSAAPP 80 PQCGPPPPPA 90 PDMTFKKEPA 100 ASAAAFPSQR 110 TSWGFLQSLE 120 QQSHHHHHHH 130 HFGGLFAGTE 140 ERSPGLGGGE 150 GGSHGVIQDL 160 SILHQHVQQQ 170 PAQHHRDVLL 180 SSSSRTDDHG 190 NEEPKQDTNV 200 KKAKRPKPES 210 QGIKAKRKPS 220 ASSKPSLVGD 230 GEGAILSPSQ 240 KPHICDHCSA 250 AFRSSYHLRR 260 HVLIHTGERP 270 FQCSQCSMGF 280 IQKYLLQRHE 290 KIHSREKPFG 300 CDQCSMKFIQ 310 KYHMERHKRT 320 HSGEKPYKCD 330 TCQQYFSRTD 340 RLLKHRRTCG 350 EAIAKGTASA 360 EPGSSNHNNM 370 GNLAALSQGN 380 TSSSRRKSKS 390 KSIPIENKEQ 400 KTGKTNESQI 410 SNNINMQSYS 420 VEMPTVSSSG 430 GIIGTGIDEL 440 QKRVPKLIFK 450 KGSRKNTDKN 460 YLNFVSPLPD 470 IVGQKSLSGK 480 PSGSLGIVSN 490 NSVETISLLQ 500 NTSGKQGQIS 510 SNYDDAMQFS 520 KKRRYLPTAS 530 SNSAFSINVG 540 HMVSQQSVIQ 550 SAGVSVLDNE 560 APLSLIDSSA 570 LNAEIKSCHD 580 KSGIPDEVLQ 590 SILDQYSNKS 600 ESQKEDPFNI 610 TEPRVDLHTS 620 GEHSELVQEE 630 NLSPGTQTPS 640 NDKASVLQEY 650 SKYLQQAFEK 660 STNAGFTLGP 670 GFQFVSLSSP 680 LHNHTLFPEK 690 QIYTTSPLEC 700 GFGQSVTSVL 710 PSSLPKPPFG 720 MLFGSQPGLY 730 LSALDATHQQ 740 LTPSQELDDL 750 IDSQKNLETS 760 SAFQSSSQKL 770 TSQKEQKNLE 780 SSTSFQIPSQ 790 ELASQIDPQK 800 DIEPRTTYQI 810 ENFAQAFGSQ 820 FKSGSRVPMT 830 FITNSNGEVD 840 HRVRTSVSDF 850 SGYTNMMSDV 860 SEPCSTRVKT PTSQSYR

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005634	nucleus
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding
Molecular Function	GO:0008270	zinc ion binding
Biological Process	GO:0030154	cell differentiation
Biological Process	GO:0006351	DNA-templated transcription

Reference

[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.