Search Results

Overview

Uniprot ID	H0VW42
Protein Name	Thimet oligopeptidase
Gene Name	THOP1
Organism	Cavia porcellus

Kla Sites from experimental identification

Position	Flanking peptide
133	WLQEKLQKDSLRPEA

Function

Involved in the metabolism of neuropeptides under 20 amino acid residues long. Involved in cytoplasmic peptide degradation. Able to degrade the amyloid-beta precursor protein and generate amyloidogenic fragments. Also acts as a regulator of cannabinoid signaling pathway by mediating degradation of hemopressin, an antagonist peptide of the cannabinoid receptor CNR1

Protein Sequence

10 MKPPAACAGD 20 MLDTVSPPRS 30 PVVNHLRWDL 40 SASQIETRTK 50 ELIEQTKRVY 60 DQVGVQAFEE 70 VSFESTLKAL 80 ADVEVTYTVQ 90 RNILDFPQHV 100 SPSKEIRVAS 110 TEADKKLSEF 120 DVEMSMRQDV 130 YQRVVWLQEK 140 LQKDSLRPEA 150 ARYLERLLKL 160 GRRNGLHLPK 170 ETQDKIKSMK 180 KKLSLLCIDF 190 NKNLNEDTTF 200 LPFTREELGG 210 LPEDFLNALE 220 KTEGDKLKVT 230 LKYPHYFPLL 240 KKCHVPETRR 250 KVEAAFNSRC 260 KEENCAILKE 270 LVALRAQKCK 280 LLGFSTHADY 290 VLEMNMAKTS 300 KAVAAFLDEL 310 AQKLKPLGEQ 320 ERAVILELKE 330 AECTRRGLPF 340 DGRIHAWDMR 350 YYMNQVEETR 360 YRVDQNLLKE 370 YFPMEVVTRG 380 LLGIYQELLG 390 LTFQLEEGAA 400 VWHEDVLLYS 410 VRDAASGELL 420 GQFYLDLYPR 430 EGKYGHAACF 440 GLQPGCLRQD 450 GSRQIAVAAM 460 VANFTKPTPD 470 APSLLQHDEV 480 ETYFHEFGHV 490 MHQLCSQAEF 500 AMFSGTHVER 510 DFVEAPSQML 520 ENWVWEKEPL 530 LRMSGHYRSG 540 HAVPQELLDK 550 LIQSRQANTG 560 LFNLRQIVLA 570 KVDQALHTGT 580 DIDPAEEYAR 590 LCQDILGVPA 600 TQGTNMPATF 610 GHLAGGYDAQ 620 YYGYLWSEVF 630 SMDMFHTRFK 640 QEGVLSPKVG 650 MDYRTTILRP 660 GGSQDASAML 670 KLFLGREPRQ 680 DAFLLSKGLP VEASEPPAC

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0005758	mitochondrial intermembrane space
Molecular Function	GO:0046872	metal ion binding
Molecular Function	GO:0004222	metalloendopeptidase activity
Biological Process	GO:0006518	peptide metabolic process
Biological Process	GO:0006508	proteolysis

Reference

[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.