Overview
| Uniprot ID | H0VWU2 |
|---|
| Protein Name | Small ubiquitin-related modifier |
|---|
| Gene Name | SUMO3 |
|---|
| Organism | Cavia porcellus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 14 |
KVSREGVKTENDHIN |
Function
Ubiquitin-like protein which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. Plays a role in the regulation of sumoylation status of SETX
Protein Sequence
10
MSEEKPKVSR
20
EGVKTENDHI
30
NLKVAGQDGS
40
VVQFKIKRHT
50
PLSKLMKAYC
60
ERQGLSMRQI
70
RFRFDGQPIN
80
ETDTPAQLEM
90
EDEDTIDVFQ
100
QQTGGAVSRG
TIAPCIRCG
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0016605 |
PML body |
| Biological Process |
GO:0016925 |
protein sumoylation |
Reference
[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.