Overview
| Uniprot ID | H0VWW4 |
| Protein Name | Nuclear receptor corepressor 2 |
| Gene Name | NCOR2 |
| Organism | Cavia porcellus |
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 1238 |
GHVIYEGKKGHVLSY |
| 1363 |
RDLAEAYKGRPLDAL |
| 1387 |
EGLVATVKEAGRSIH |
| 1415 |
PLAPRPLKEGSITQG |
| 1437 |
GTSSASSKKHDVRSI |
| 1477 |
ACYEENLKGRPGAAG |
| 2232 |
ESNSAMVKSKKQEIN |
| 335 |
KVREYYEKQFPEIRK |
| 958 |
PQKPLDLKQLKQRAA |
Function
Transcriptional corepressor that mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription. Acts by recruiting chromatin modifiers, such as histone deacetylases HDAC1, HDAC2 and HDAC3. Required to activate the histone deacetylase activity of HDAC3. Involved in the regulation BCL6-dependent of the germinal center (GC) reactions, mainly through the control of the GC B-cells proliferation and survival. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation
Protein Sequence
10
MSGSTQPVAQ
20
TWRAAEPRYP
30
PHGISYPVQI
40
TRPHTDVGLL
50
EYQHHPRDYT
60
SHLSPGSIIQ
70
PQRRRPSLLS
80
EFQPGNERSQ
90
ELHLRPESHS
100
YLPELGKADL
110
EFMESKRPRL
120
ELMSDPLLRP
130
SPLLATGQPC
140
ASEDLSKDRS
150
LGGKLEPVSP
160
PSPPHADAEL
170
ELAPPRLSKE
180
ELIQNMDRVD
190
REITMVEQQI
200
SKLKKKQQQL
210
EEEAAKPPEP
220
EKPVSPPPIE
230
SKHRSLVQII
240
YDENRKKAEA
250
AHRILEGLGP
260
QVELPLYNQP
270
SDTRQYHENI
280
KINQAMRKKL
290
ILYFKRRNHA
300
RKQWEQKFCQ
310
RYDQLMEAWE
320
KKVERIENNP
330
RRRAKESKVR
340
EYYEKQFPEI
350
RKQRELQERM
360
QSRVGQRGSG
370
LSMSAARSEH
380
EVSEIIDGLS
390
EQENLEKQMR
400
QLAVIPPMLY
410
DADQQRIKFI
420
NMNGLMDDPM
430
KVYKDRQVMN
440
MWSEQEKETF
450
REKFMQHPKN
460
FGLIASFLER
470
KTVAECVLYY
480
YLTKKNENYK
490
SLVRRSYRRR
500
GKSQVRQQQQ
510
PPPPPRSSQE
520
EKEEKEKEAE
530
KEEEKPDVEN
540
GKEELIKEKT
550
DDTSGEDNDE
560
REAVASKGRK
570
TANSQGRRKG
580
RITRSMASEA
590
NSDEAVTPQQ
600
SAELASLEMN
610
ESSRWTEEEM
620
ETAKKGLLEH
630
GRNWSAIARM
640
VGSKTVSQCK
650
NFYFNYKKRQ
660
NLDDILQQHK
670
LKMEKERNAR
680
RKKKKAPATA
690
SEEAAFPPVV
700
EDEEMEASGA
710
SGNEEEMAEE
720
AEALPVPGSE
730
VSRGECSGPA
740
TVNNGSDTES
750
VPSPRASEAT
760
KEPKPPPTAV
770
PDGLPAPPPT
780
PPPDDAPTPV
790
EPAPGPEASG
800
RPTSPAAPSS
810
PAVAPAVAPK
820
EEEVEEAAMA
830
VPPAEDREEQ
840
KPQAPEQLAG
850
DLGKVEEPGA
860
APKELVQSVC
870
VPEAAETALT
880
RSLEDTPEGA
890
PEGPLKTEKK
900
EGAGGKASAA
910
KSSGTPQDSD
920
SSATCSADEV
930
DEPEGSDKGR
940
LLSPRPSLLT
950
PGGDPRASAS
960
PQKPLDLKQL
970
KQRAAAIPPI
980
VTKTHEPSQE
990
DAALPQLAPA
1000
PPPPAQHLQP
1010
ESDAPHHPSS
1020
SPQGKRSPVP
1030
SAEKEAEKPT
1040
FFPAFAAEGQ
1050
KLPAEPPCWT
1060
SGLPFPMPPR
1070
EVIKASPHAP
1080
DASAFSYTPP
1090
GHPLPLSLHE
1100
GARPGPPRPP
1110
TISNPPPLIS
1120
SAKHPGVLER
1130
QMGTITQGVS
1140
VQLHGPFSEH
1150
AKAPVGPVTM
1160
GLPLAMDPKK
1170
LGTALGSVPG
1180
GSITRGIPST
1190
RAPPESPGTY
1200
RGSITHGTPA
1210
DVLYKGTITR
1220
IVGEESPSRL
1230
DRAREDSLPK
1240
GHVIYEGKKG
1250
HVLSYEGAMQ
1260
VSQCSKEDGR
1270
SSSGPAHEPA
1280
APKRTYDMME
1290
GRVGRALASA
1300
GIEGLMGRAI
1310
PPEHHSPHHL
1320
KEQHHLRGSI
1330
TQGTPRSYVE
1340
AQEDYLRREA
1350
KLLKREGSPP
1360
PPPPPRDLAE
1370
AYKGRPLDAL
1380
GPLKLKPAHE
1390
GLVATVKEAG
1400
RSIHEIPREE
1410
LRHTPELPLA
1420
PRPLKEGSIT
1430
QGTPLKYDTG
1440
TSSASSKKHD
1450
VRSIIGSPGR
1460
TFPPVLPLDV
1470
VADARVLERA
1480
CYEENLKGRP
1490
GAAGGSGGSI
1500
TRGAPVVVPE
1510
LGKPRQSPLT
1520
YEDHAAAFAS
1530
HLPRGSPVTT
1540
REPTPRLQEG
1550
DLLSSKTSQD
1560
RKLTSTPREV
1570
ARSPHSTVPE
1580
HPPHPMSPYE
1590
HLLRGVSGVD
1600
LYRSHIPLAF
1610
DPASISRGIP
1620
LDAAAAYYLP
1630
RHLAPNPTYP
1640
HLYPPYLIRG
1650
YPDTAALENR
1660
QTIINDYITS
1670
QQMHHSAATA
1680
MAQRADMLRG
1690
LSPRESSLAL
1700
NYATGPRGII
1710
DLSQVPHLPV
1720
LVPPTPSAPA
1730
AAMERLAYLP
1740
AAPQPFGSRH
1750
SSSPLSPGGP
1760
SHLTKPTAVS
1770
SSERERERDR
1780
ERDKSILTST
1790
TTVEHAPIWR
1800
PGTEQSSGSG
1810
SSGSRPTTHT
1820
HAHQHSPISP
1830
RTQDALQQRP
1840
SVLHNAGMKG
1850
LITSVEPSTP
1860
TVLRSTSTSS
1870
PIRLAATFPP
1880
TTHCPLGSTL
1890
DGVYPTLMEP
1900
VLLPKESTRG
1910
TRTERPRTDT
1920
GHAFLTKPPA
1930
REPTSSPSKS
1940
SEPRPLAPPS
1950
SSHAAITHTP
1960
AKSLAPHHAS
1970
PDPPAPPNSA
1980
SDPHRGKTQS
1990
KPFSIQELEL
2000
RSLGYHGYSP
2010
EGVEPVSPVS
2020
SPSLTQDKGL
2030
PKHLEELDKG
2040
HLEGELRHKP
2050
PGPGKIGGEA
2060
THLPHLRPVP
2070
ESQTASSPLL
2080
QTAPGVKGHQ
2090
RVVTLAQHIS
2100
EVITQDYTRH
2110
HPQQLSTTLP
2120
APLYSFPGAS
2130
CPVLDLRRPP
2140
SDLYLPHPEH
2150
NTPARGSPHS
2160
EGGKRSPEPS
2170
KTLVLGGEDG
2180
IEPVSPPESM
2190
SEPGHARSAM
2200
YPLLYRDGEQ
2210
AEPRMGSKSP
2220
GNTSQPPAFF
2230
SKLTESNSAM
2240
VKSKKQEINK
2250
KLNTHNRNEP
2260
EYNIGQPGTE
2270
IFNMPAITGA
2280
GLMTCRSQAV
2290
PEHTSTSMGL
2300
EAIIRKALMG
2310
KYDQWEEPPP
2320
LGANAFNPLN
2330
ASASLPTAAM
2340
PVTAAADGRS
2350
DPALTSPGGG
2360
GKAKVSGRPS
2370
SRKAKSPAPG
2380
LASGDRPPSV
2390
SSVHSEGDCN
2400
RRTPLTNRVW
2410
EDRPSSAGST
2420
PFPFNPLIMR
2430
LQAGVTASPP
2440
PPGLAAGSGP
2450
LAGAHHAWEE
2460
EPKPLLCSQY
ETLSDSE
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0000785 |
chromatin |
| Cellular Component |
GO:0016604 |
nuclear body |
| Cellular Component |
GO:0016363 |
nuclear matrix |
| Cellular Component |
GO:0017053 |
transcription repressor complex |
| Molecular Function |
GO:0003677 |
DNA binding |
| Molecular Function |
GO:0008047 |
enzyme activator activity |
| Molecular Function |
GO:0042826 |
histone deacetylase binding |
| Molecular Function |
GO:0005112 |
Notch binding |
| Molecular Function |
GO:0003714 |
transcription corepressor activity |
| Biological Process |
GO:0006351 |
DNA-templated transcription |
| Biological Process |
GO:0061436 |
establishment of skin barrier |
| Biological Process |
GO:0001701 |
in utero embryonic development |
| Biological Process |
GO:0060766 |
negative regulation of androgen receptor signaling pathway |
| Biological Process |
GO:1902894 |
negative regulation of miRNA transcription |
| Biological Process |
GO:0000122 |
negative regulation of transcription by RNA polymerase II |
| Biological Process |
GO:0050821 |
protein stabilization |
| Biological Process |
GO:0010565 |
regulation of ketone metabolic process |
Reference
[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.