Search Results

Overview

Uniprot IDH0VWW4
Protein NameNuclear receptor corepressor 2
Gene NameNCOR2
OrganismCavia porcellus

Kla Sites from experimental identification

Position Flanking peptide
1238 GHVIYEGKKGHVLSY
1363 RDLAEAYKGRPLDAL
1387 EGLVATVKEAGRSIH
1415 PLAPRPLKEGSITQG
1437 GTSSASSKKHDVRSI
1477 ACYEENLKGRPGAAG
2232 ESNSAMVKSKKQEIN
335 KVREYYEKQFPEIRK
958 PQKPLDLKQLKQRAA

Function

Transcriptional corepressor that mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription. Acts by recruiting chromatin modifiers, such as histone deacetylases HDAC1, HDAC2 and HDAC3. Required to activate the histone deacetylase activity of HDAC3. Involved in the regulation BCL6-dependent of the germinal center (GC) reactions, mainly through the control of the GC B-cells proliferation and survival. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation

Protein Sequence

10 MSGSTQPVAQ 20 TWRAAEPRYP 30 PHGISYPVQI 40 TRPHTDVGLL 50 EYQHHPRDYT 60 SHLSPGSIIQ 70 PQRRRPSLLS 80 EFQPGNERSQ 90 ELHLRPESHS 100 YLPELGKADL 110 EFMESKRPRL 120 ELMSDPLLRP 130 SPLLATGQPC 140 ASEDLSKDRS 150 LGGKLEPVSP 160 PSPPHADAEL 170 ELAPPRLSKE 180 ELIQNMDRVD 190 REITMVEQQI 200 SKLKKKQQQL 210 EEEAAKPPEP 220 EKPVSPPPIE 230 SKHRSLVQII 240 YDENRKKAEA 250 AHRILEGLGP 260 QVELPLYNQP 270 SDTRQYHENI 280 KINQAMRKKL 290 ILYFKRRNHA 300 RKQWEQKFCQ 310 RYDQLMEAWE 320 KKVERIENNP 330 RRRAKESKVR 340 EYYEKQFPEI 350 RKQRELQERM 360 QSRVGQRGSG 370 LSMSAARSEH 380 EVSEIIDGLS 390 EQENLEKQMR 400 QLAVIPPMLY 410 DADQQRIKFI 420 NMNGLMDDPM 430 KVYKDRQVMN 440 MWSEQEKETF 450 REKFMQHPKN 460 FGLIASFLER 470 KTVAECVLYY 480 YLTKKNENYK 490 SLVRRSYRRR 500 GKSQVRQQQQ 510 PPPPPRSSQE 520 EKEEKEKEAE 530 KEEEKPDVEN 540 GKEELIKEKT 550 DDTSGEDNDE 560 REAVASKGRK 570 TANSQGRRKG 580 RITRSMASEA 590 NSDEAVTPQQ 600 SAELASLEMN 610 ESSRWTEEEM 620 ETAKKGLLEH 630 GRNWSAIARM 640 VGSKTVSQCK 650 NFYFNYKKRQ 660 NLDDILQQHK 670 LKMEKERNAR 680 RKKKKAPATA 690 SEEAAFPPVV 700 EDEEMEASGA 710 SGNEEEMAEE 720 AEALPVPGSE 730 VSRGECSGPA 740 TVNNGSDTES 750 VPSPRASEAT 760 KEPKPPPTAV 770 PDGLPAPPPT 780 PPPDDAPTPV 790 EPAPGPEASG 800 RPTSPAAPSS 810 PAVAPAVAPK 820 EEEVEEAAMA 830 VPPAEDREEQ 840 KPQAPEQLAG 850 DLGKVEEPGA 860 APKELVQSVC 870 VPEAAETALT 880 RSLEDTPEGA 890 PEGPLKTEKK 900 EGAGGKASAA 910 KSSGTPQDSD 920 SSATCSADEV 930 DEPEGSDKGR 940 LLSPRPSLLT 950 PGGDPRASAS 960 PQKPLDLKQL 970 KQRAAAIPPI 980 VTKTHEPSQE 990 DAALPQLAPA 1000 PPPPAQHLQP 1010 ESDAPHHPSS 1020 SPQGKRSPVP 1030 SAEKEAEKPT 1040 FFPAFAAEGQ 1050 KLPAEPPCWT 1060 SGLPFPMPPR 1070 EVIKASPHAP 1080 DASAFSYTPP 1090 GHPLPLSLHE 1100 GARPGPPRPP 1110 TISNPPPLIS 1120 SAKHPGVLER 1130 QMGTITQGVS 1140 VQLHGPFSEH 1150 AKAPVGPVTM 1160 GLPLAMDPKK 1170 LGTALGSVPG 1180 GSITRGIPST 1190 RAPPESPGTY 1200 RGSITHGTPA 1210 DVLYKGTITR 1220 IVGEESPSRL 1230 DRAREDSLPK 1240 GHVIYEGKKG 1250 HVLSYEGAMQ 1260 VSQCSKEDGR 1270 SSSGPAHEPA 1280 APKRTYDMME 1290 GRVGRALASA 1300 GIEGLMGRAI 1310 PPEHHSPHHL 1320 KEQHHLRGSI 1330 TQGTPRSYVE 1340 AQEDYLRREA 1350 KLLKREGSPP 1360 PPPPPRDLAE 1370 AYKGRPLDAL 1380 GPLKLKPAHE 1390 GLVATVKEAG 1400 RSIHEIPREE 1410 LRHTPELPLA 1420 PRPLKEGSIT 1430 QGTPLKYDTG 1440 TSSASSKKHD 1450 VRSIIGSPGR 1460 TFPPVLPLDV 1470 VADARVLERA 1480 CYEENLKGRP 1490 GAAGGSGGSI 1500 TRGAPVVVPE 1510 LGKPRQSPLT 1520 YEDHAAAFAS 1530 HLPRGSPVTT 1540 REPTPRLQEG 1550 DLLSSKTSQD 1560 RKLTSTPREV 1570 ARSPHSTVPE 1580 HPPHPMSPYE 1590 HLLRGVSGVD 1600 LYRSHIPLAF 1610 DPASISRGIP 1620 LDAAAAYYLP 1630 RHLAPNPTYP 1640 HLYPPYLIRG 1650 YPDTAALENR 1660 QTIINDYITS 1670 QQMHHSAATA 1680 MAQRADMLRG 1690 LSPRESSLAL 1700 NYATGPRGII 1710 DLSQVPHLPV 1720 LVPPTPSAPA 1730 AAMERLAYLP 1740 AAPQPFGSRH 1750 SSSPLSPGGP 1760 SHLTKPTAVS 1770 SSERERERDR 1780 ERDKSILTST 1790 TTVEHAPIWR 1800 PGTEQSSGSG 1810 SSGSRPTTHT 1820 HAHQHSPISP 1830 RTQDALQQRP 1840 SVLHNAGMKG 1850 LITSVEPSTP 1860 TVLRSTSTSS 1870 PIRLAATFPP 1880 TTHCPLGSTL 1890 DGVYPTLMEP 1900 VLLPKESTRG 1910 TRTERPRTDT 1920 GHAFLTKPPA 1930 REPTSSPSKS 1940 SEPRPLAPPS 1950 SSHAAITHTP 1960 AKSLAPHHAS 1970 PDPPAPPNSA 1980 SDPHRGKTQS 1990 KPFSIQELEL 2000 RSLGYHGYSP 2010 EGVEPVSPVS 2020 SPSLTQDKGL 2030 PKHLEELDKG 2040 HLEGELRHKP 2050 PGPGKIGGEA 2060 THLPHLRPVP 2070 ESQTASSPLL 2080 QTAPGVKGHQ 2090 RVVTLAQHIS 2100 EVITQDYTRH 2110 HPQQLSTTLP 2120 APLYSFPGAS 2130 CPVLDLRRPP 2140 SDLYLPHPEH 2150 NTPARGSPHS 2160 EGGKRSPEPS 2170 KTLVLGGEDG 2180 IEPVSPPESM 2190 SEPGHARSAM 2200 YPLLYRDGEQ 2210 AEPRMGSKSP 2220 GNTSQPPAFF 2230 SKLTESNSAM 2240 VKSKKQEINK 2250 KLNTHNRNEP 2260 EYNIGQPGTE 2270 IFNMPAITGA 2280 GLMTCRSQAV 2290 PEHTSTSMGL 2300 EAIIRKALMG 2310 KYDQWEEPPP 2320 LGANAFNPLN 2330 ASASLPTAAM 2340 PVTAAADGRS 2350 DPALTSPGGG 2360 GKAKVSGRPS 2370 SRKAKSPAPG 2380 LASGDRPPSV 2390 SSVHSEGDCN 2400 RRTPLTNRVW 2410 EDRPSSAGST 2420 PFPFNPLIMR 2430 LQAGVTASPP 2440 PPGLAAGSGP 2450 LAGAHHAWEE 2460 EPKPLLCSQY ETLSDSE

Gene Ontology

Classification GO ID Description
Cellular Component GO:0000785 chromatin
Cellular Component GO:0016604 nuclear body
Cellular Component GO:0016363 nuclear matrix
Cellular Component GO:0017053 transcription repressor complex
Molecular Function GO:0003677 DNA binding
Molecular Function GO:0008047 enzyme activator activity
Molecular Function GO:0042826 histone deacetylase binding
Molecular Function GO:0005112 Notch binding
Molecular Function GO:0003714 transcription corepressor activity
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0061436 establishment of skin barrier
Biological Process GO:0001701 in utero embryonic development
Biological Process GO:0060766 negative regulation of androgen receptor signaling pathway
Biological Process GO:1902894 negative regulation of miRNA transcription
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0050821 protein stabilization
Biological Process GO:0010565 regulation of ketone metabolic process

Reference

[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.