Search Results
Overview
| Uniprot ID | H0VZ77 |
|---|---|
| Protein Name | Peroxiredoxin-5 |
| Gene Name | PRDX5 |
| Organism | Cavia porcellus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 86 | VNLAELFKGKKGVLF |
Function
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events
Protein Sequence
10
MGLAQLSALG
20
HLAGTVLCGT
30
VVRQGAAAAA
40
SRRSVEGAGG
50
WARDRARGFC
60
STAAAMAPIK
70
VGDAIPSVEV
80
FEGEPGNKVN
90
LAELFKGKKG
100
VLFGVPGAFT
110
PGCSKTHLPG
120
FVEQAGALKA
130
KGVQVVACLS
140
VNDVFVIGEW
150
GKAHKAEGKI
160
RLLADPTGAF
170
GKETDLLLDN
180
SLVPLFGNRR
190
LKRFSMVIEN
200
GVVKSLNVEP
210
DGTGLTCSLA
SNILSQL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0031410 | cytoplasmic vesicle |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Cellular Component | GO:0005782 | peroxisomal matrix |
| Molecular Function | GO:0043027 | cysteine-type endopeptidase inhibitor activity involved in apoptotic process |
| Molecular Function | GO:0001016 | RNA polymerase III transcription regulatory region sequence-specific DNA binding |
| Molecular Function | GO:0008379 | thioredoxin peroxidase activity |
| Biological Process | GO:0045454 | cell redox homeostasis |
| Biological Process | GO:0034614 | cellular response to reactive oxygen species |
| Biological Process | GO:0042744 | hydrogen peroxide catabolic process |
| Biological Process | GO:0043066 | negative regulation of apoptotic process |
| Biological Process | GO:0016480 | negative regulation of transcription by RNA polymerase III |
Reference
[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.