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Overview

Uniprot IDH0VZD9
Protein NameATP synthase subunit beta
Gene NameATP5F1B
OrganismCavia porcellus

Kla Sites from experimental identification

Position Flanking peptide
124 EGLVRGQKVLDSGAP
133 LDSGAPIKIPVGPET
443 MGKLVPLKETIKGFQ
480 EAVAKADKLAEEHAS

Function

Catalytic subunit beta, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro. With the subunit alpha (ATP5F1A), forms the catalytic core in the F(1) domain

Protein Sequence

10 MLSLVGRVAA 20 ASACGALRGL 30 SPSASLPQPQ 40 LLLRASPAAV 50 QPARDYAAQT 60 SPSPKPGAAT 70 GRIVAVIGAV 80 VDVQFDEGLP 90 PILNALEVQG 100 RDTRLVLEVA 110 QHLGESTVRT 120 IAMDGTEGLV 130 RGQKVLDSGA 140 PIKIPVGPET 150 LGRIMNVIGE 160 PIDERGPIKT 170 KLFGGAGVGK 180 TVLIMELINN 190 VAKAHGGYSV 200 FAGVGERTRE 210 GNDLYHEMIE 220 SGVINLKDAT 230 SKVALVYGQM 240 NEPPGARARV 250 ALTGLTVAEY 260 FRDQEGQDVL 270 LFIDNIFRFT 280 QAGSEVSALL 290 GRIPSAVGYQ 300 PTLATDMGTM 310 QERITTTKKG 320 SITSVQAIYV 330 PADDLTDPAP 340 ATTFAHLDAT 350 TVLSRAIAEL 360 GIYPAVDPLD 370 STSRIMDPNI 380 VGSEHYDVAR 390 GVQKILQDYK 400 SLQDIIAILG 410 MDELSEEDKL 420 TVSRARKIQR 430 FLSQPFQVAE 440 VFTGHMGKLV 450 PLKETIKGFQ 460 QILAGDYDHL 470 PEQAFYMVGP 480 IEEAVAKADK LAEEHAS

Gene Ontology

Classification GO ID Description
Cellular Component GO:0009986 cell surface
Cellular Component GO:0031966 mitochondrial membrane
Cellular Component GO:0042645 mitochondrial nucleoid
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0045259 proton-transporting ATP synthase complex
Molecular Function GO:0043532 angiostatin binding
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0042288 MHC class I protein binding
Molecular Function GO:0046933 proton-transporting ATP synthase activity, rotational mechanism
Molecular Function GO:0046961 proton-transporting ATPase activity, rotational mechanism
Biological Process GO:0001525 angiogenesis
Biological Process GO:0043536 positive regulation of blood vessel endothelial cell migration
Biological Process GO:0042776 proton motive force-driven mitochondrial ATP synthesis
Biological Process GO:0051453 regulation of intracellular pH

Reference

[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.