Search Results
Overview
| Uniprot ID | H0W051 |
|---|---|
| Protein Name | Gamma-synuclein |
| Gene Name | SNCG |
| Organism | Cavia porcellus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 34 | TEAAEKTKEGVMYVG |
| 45 | MYVGAKTKENVVQSV |
Function
Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to calcium-dependent proteases. May also function in modulating the keratin network in skin. Activates the MAPK and Elk-1 signal transduction pathway
Protein Sequence
10
MDVFKKGFSI
20
AREGVVGAVE
30
KTKQGVTEAA
40
EKTKEGVMYV
50
GAKTKENVVQ
60
SVTSVAEKTK
70
EQANAVSEAV
80
VTSVNTVATK
90
TVEEAENIVV
100
TAGVVRKASG
GN
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0043679 | axon terminus |
| Cellular Component | GO:0005813 | centrosome |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0043025 | neuronal cell body |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Cellular Component | GO:0005819 | spindle |
| Molecular Function | GO:1903136 | cuprous ion binding |
| Biological Process | GO:0007268 | chemical synaptic transmission |
| Biological Process | GO:0009306 | protein secretion |
| Biological Process | GO:0050808 | synapse organization |
| Biological Process | GO:0048488 | synaptic vesicle endocytosis |
Reference
[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.